Short term cadmium administration dose dependently elicits immediate biochemical, neurochemical and neurobehavioral dysfunction in male rats

莫里斯水上航行任务 乙酰胆碱酯酶 行为绝望测验 超氧化物歧化酶 氯化镉 脂质过氧化 内科学 内分泌学 医学 化学 神经化学 阿切 开阔地 神经毒性 毒性 氧化应激 药理学 谷胱甘肽 多巴胺 谷胱甘肽过氧化物酶 高架加迷宫 海马体 海马结构 生物化学 焦虑 有机化学 抗抑郁药 精神科
作者
Saida Haider,Lubna Anis,Zehra Batool,Irfan Sajid,Fizza Naqvi,Saima Khaliq,Shoaib Ahmed
出处
期刊:Metabolic Brain Disease [Springer Nature]
卷期号:30 (1): 83-92 被引量:30
标识
DOI:10.1007/s11011-014-9578-4
摘要

Cadmium is a toxic environmental and industrial pollutant. Cadmium toxicity has been reported to produce biochemical and behavioral dysfunction that may cause adverse effects on several organs including the central nervous system. The present study was designed to investigate the neurotoxic effects of Cadmium Chloride (CdCl2) at three different doses by using different behavioral models. Lipid peroxidation (LPO), superoxide dismutase (SOD) and acetylcholinesterase (AChE) activities were also monitored following acute intraperitoneal injection of cadmium. Twenty four adult locally bred Albino Wistar rats were divided into control and 3 test groups (n = 6). Control rats were injected intraperitoneally with saline (0.9% NaCl) and test groups were injected with CdCl2 (1 mg/kg, 2 mg/kg and 3 mg/kg) dissolved in physiological solution. Behavioral activities of rats were monitored after 1 h of cadmium injection. Locomotor activity and depression-like symptoms were measured by Open Field Test (OFT) and Forced Swimming Test (FST) respectively. Anxiety like behavior was monitored using Light-dark Transition (LDT) test and memory functions of rats were assessed by Morris Water Maze test (MWM). In the present study acute cadmium administration dose dependently increased anxiety in rats as compared to control rats. A significant increase in depression-like symptoms was also exhibited by cadmium treated rats. These behavioral dysfunctions may be attributed to the decreased superoxide dismutase (SOD) activity and simultaneously increased brain lipid peroxidation (LPO). Moreover learning and memory assessed by MWM showed dose dependent impairment in memory function in cadmium treated rats as compared to control rats. Acetylcholinesterase (AChE) activity was also decreased in brains of cadmium administered rats. It is suggested in this study that behavioral, biochemical and neurochemical dysfunctions caused by acute cadmium administration occur in a dose dependent manner.
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