精神病
神经心理学
帕金森病
运动障碍
心理学
精神科
毒品天真
内表型
疾病
医学
儿科
内科学
认知
药品
作者
Javier Pagonabarraga,Saül Martínez‐Horta,Ramón Fernández de Bobadilla,Jesús Pérez‐Pérez,Roser Ribosa‐Nogué,Juan Marín‐Lahoz,Berta Pascual‐Sedano,Carmen Vega,Alexandre Gironell,Jaime Kulisevsky
摘要
Abstract Objectives The description of minor hallucinatory phenomena (presence, passage hallucinations) has widened the spectrum of psychosis in Parkinson's disease (PD). Minor hallucinatory phenomena seem to antedate the development of more severe hallucinations. Early detection of minor hallucinations may be useful for screening patients with more severe endophenotypes. Motivated by the observation of “de novo,” drug‐naive PD patients reporting minor hallucinations, we aimed to prospectively identify “de novo” untreated PD patients experiencing hallucinatory phenomena, and to compare their clinico‐demographic characteristics with those of untreated PD patients without hallucinations and healthy controls. Methods Screening and description of psychosis was assessed by the Movement Disorders Society Unified Parkinson's Disease Rating Scale—Part I and a structured interview covering all types of psychotic phenomena reported in PD. Clinical, neuropsychological, and demographic data of PD patients with and without psychotic phenomena were compared with those of age‐ and education‐matched healthy controls. Results Fifty drug‐naive, “de novo” PD patients and 100 controls were prospectively included. Minor hallucinations were experienced in 42% (21 of 50) PD patients and 5% controls ( P < 0.0001). Coexistence of passage and presence hallucinations was the most common finding. Unexpectedly, 33.3% of patients with minor hallucinations manifested these as a pre‐motor symptom, starting 7 months to 8 years before first parkinsonian motor symptoms. The presence of minor hallucinations was significantly associated with presence of rapid eye movement sleep behavior disorder. Conclusions In this first study to prospectively analyze the frequency of minor hallucinatory phenomena in incident, untreated PD patients, hallucinations appeared as a frequent early non‐motor symptom that may even predate the onset of parkinsonism. © 2015 International Parkinson and Movement Disorder Society
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