医学
胎龄
优势比
工作记忆
儿科
认知
言语记忆
神经心理学测验
妊娠期
剑桥神经心理学测试自动电池
队列
睡眠剥夺对认知功能的影响
神经心理学
怀孕
空间记忆
精神科
内科学
遗传学
生物
作者
Alyssa Fitzpatrick,Jennifer Carter,Maria Quigley
出处
期刊:Pediatrics
[American Academy of Pediatrics]
日期:2016-12-01
卷期号:138 (6)
被引量:26
标识
DOI:10.1542/peds.2016-0578
摘要
BACKGROUND: Although children born very preterm (gestation <32 weeks) have an increased risk of cognitive impairment compared with full-term children (39–41 weeks), the risk for children born moderately (32–33 weeks) to late preterm (34–36 weeks) and early term (37–38 weeks) is unclear. This study describes the relationship between gestational age and cognitive outcomes at 11 years and the trajectory of deficits in verbal ability from age 3 to 11 years. METHODS: Cognitive ability was assessed by using the Spatial Working Memory test from the Cambridge Neuropsychological Test Automated Working Battery (n = 11 395) and British Ability Scale Verbal Similarities test (n = 11 889) in the UK Millennium Cohort Study. Each gestational group was compared with the full-term group by using differences in z scores and odds ratios for delay (scoring ≥1 SD below the mean). RESULTS: Very and moderately preterm children demonstrated significantly lower working memory scores compared with full-term children (adjusted difference –0.2 to –0.6) and were more likely to be delayed. There was no significant relationship between late-preterm or early-term birth and working memory (adjusted differences < –0.1), or between gestational age and verbal ability at 11 years. There appears to be a general attenuation in odds ratios as the child ages. CONCLUSIONS: Very preterm children exhibited working memory deficits at 11 years. However, the absence of delayed verbal skills at 11 years despite earlier delays could indicate “catch-up” effects.
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