细胞毒性
阿霉素
材料科学
苯硼酸
盐酸阿霉素
明胶
渗透(战争)
生物物理学
体外
药物输送
动态光散射
纳米颗粒
纳米技术
生物化学
化学
生物
化疗
催化作用
工程类
遗传学
运筹学
作者
Xin Wang,Bing Wei,Xu Cheng,Jun Wang,Rupei Tang
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2016-08-11
卷期号:27 (38): 385101-385101
被引量:32
标识
DOI:10.1088/0957-4484/27/38/385101
摘要
Phenylboronic acid-decorated nanoparticles (NPs) were prepared for tumor-targeted drug delivery. 3-carboxyphenylboronic acid (3-CPBA) was modified on the surface of conventional gelatin NPs (designated as NP1) to give tumor-targeting NPs (designated as NP2). The morphology and stability of NP1 and NP2 were then investigated using transmission electron microscopy, scanning electron microscopy, and dynamic light scattering. The results show that both NP1 and NP2 are spherical-like and kinetically stable under various conditions. Doxorubicin hydrochloride (DOX) was used as a model anticancer drug and was loaded into NP1 (NP1-DOX) and NP2 (NP2-DOX). The i n vitro cellular uptake and cytotoxicity of NP1-DOX and NP2-DOX were measured using SH-SY5Y cells, H22 cells, and HepG2 cells. Tumor penetration, accumulation, and antitumor activity were investigated using SH-SY5Y tumor-like spheroids and H22 tumor-bearing mice. All results demonstrated that the conjugation of 3-CPBA can efficiently enhance non-targeted NPs' tumor-homing activity, thus improving their tumor accumulation and antitumor effect.
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