波形蛋白
蛋白激酶A
cGMP依赖性蛋白激酶
磷酸化
激酶
体外
细胞生物学
蛋白激酶抑制剂
化学
蛋白激酶C
细胞周期蛋白依赖激酶2
生物
生物化学
免疫学
免疫组织化学
作者
Todd A. Wyatt,K B Pryzwansky,Thomas Lincoln
出处
期刊:PubMed
日期:1991-10-01
卷期号:74 (1): 3-14
被引量:26
摘要
The effectiveness of the cGMP-dependent protein kinase inhibitor, KT5823, was investigated in human neutrophils. KT5823 did not inhibit the cGMP-dependent protein kinase mediated in vitro, or in situ phosphorylation of vimentin, a known substrate for this enzyme in activated neutrophils. In addition, KT5823 was shown to induce dramatic shape changes in neutrophils, suggesting it has an activating effect upon the cells.
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