Photothermal Therapy: Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells (Adv. Mater. 23/2019)

Advanced MaterialsVolume 31, Issue 23 1970166 FrontispieceFree Access Photothermal Therapy: Photothermal Therapy Promotes Tumor Infiltration and Antitumor Activity of CAR T Cells (Adv. Mater. 23/2019) Qian Chen, Qian Chen Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA, 90095 USA Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USA Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 199 Ren'ai Road, Suzhou, 215123 Jiangsu, P. R. ChinaSearch for more papers by this authorQuanyin Hu, Quanyin Hu Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA, 90095 USA Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USASearch for more papers by this authorElena Dukhovlinova, Elena Dukhovlinova Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599 USASearch for more papers by this authorGuojun Chen, Guojun Chen Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA, 90095 USASearch for more papers by this authorSarah Ahn, Sarah Ahn Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599 USASearch for more papers by this authorChao Wang, Chao Wang Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USA Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 199 Ren'ai Road, Suzhou, 215123 Jiangsu, P. R. ChinaSearch for more papers by this authorEdikan A. Ogunnaike, Edikan A. Ogunnaike Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599 USASearch for more papers by this authorFrances S. Ligler, Frances S. Ligler Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USASearch for more papers by this authorGianpietro Dotti, Gianpietro Dotti Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599 USASearch for more papers by this authorZhen Gu, Zhen Gu Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA, 90095 USA Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USASearch for more papers by this author Qian Chen, Qian Chen Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA, 90095 USA Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USA Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 199 Ren'ai Road, Suzhou, 215123 Jiangsu, P. R. ChinaSearch for more papers by this authorQuanyin Hu, Quanyin Hu Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA, 90095 USA Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USASearch for more papers by this authorElena Dukhovlinova, Elena Dukhovlinova Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599 USASearch for more papers by this authorGuojun Chen, Guojun Chen Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA, 90095 USASearch for more papers by this authorSarah Ahn, Sarah Ahn Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599 USASearch for more papers by this authorChao Wang, Chao Wang Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USA Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, 199 Ren'ai Road, Suzhou, 215123 Jiangsu, P. R. ChinaSearch for more papers by this authorEdikan A. Ogunnaike, Edikan A. Ogunnaike Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USA Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599 USASearch for more papers by this authorFrances S. Ligler, Frances S. Ligler Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USASearch for more papers by this authorGianpietro Dotti, Gianpietro Dotti Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, 27599 USASearch for more papers by this authorZhen Gu, Zhen Gu Department of Bioengineering, California NanoSystems Institute, Jonsson Comprehensive Cancer Center and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, CA, 90095 USA Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC, 27695 USASearch for more papers by this author First published: 03 June 2019 https://doi.org/10.1002/adma.201970166Citations: 15AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract CAR-T lymphocytes show modest therapeutic efficacy in solid tumors. Mild hyperthermia of the tumor reduces its compact structure and interstitial fluid pressure (IFP), increases blood perfusion, releases antigens, and promotes the recruitment of endogenous immune cells. In article number 1900192, Gianpietro Dotti, Zhen Gu, and co-workers find that CSPG4-specific CAR-T cells infused in NSG mice engrafted with the human melanoma WM115 cell line had superior antitumor activity after photothermal ablation of the tumor. These findings suggest that photothermal therapy facilitates the accumulation and effector function of CAR-T cells within tumors. Citing Literature Volume31, Issue23June 6, 20191970166 RelatedInformation