Anatomically based simulation of hepatic perfusion in the human liver

门静脉压 灌注 动脉树 血流 动脉 医学 压力梯度 肝静脉 静脉 放射科 门静脉 心脏病学 生物医学工程 内科学 门脉高压 物理 机械 肝硬化
作者
Renfei Ma,Peter Hunter,Will Cousins,Harvey Ho,Adam Bartlett,Soroush Safaei
出处
期刊:International Journal for Numerical Methods in Biomedical Engineering [Wiley]
卷期号:35 (9) 被引量:20
标识
DOI:10.1002/cnm.3229
摘要

Liver structures of a healthy subject are digitised and segmented from computed tomography (CT) images, and hepatic perfusion is modelled in the hepatic artery and portal vein of the healthy subject with structured tree-based outflow boundary conditions. This self-similar structured tree is widely used in the literature, eg, blood flow simulation in larger systemic arteries and cerebral circulation, and is used in this study to model the effect of the smaller hepatic arteries and arterioles, as well as the smaller hepatic portal veins and portal venules. Physiologically reasonable results are obtained. Since the structured tree terminates at the size of the microvasculature system in liver lobules, the structured tree boundary condition will enable the proposed organ-level model of hepatic arterial flow to be easily connected to tissue-level models of liver lobules. Blood flow in the hepatic vein is also modelled in this subject with three-element Windkessel model as outflow boundary conditions. The benefit of integrating the perfusion in all hepatic vascular vessels is that it helps us analyse some complicated clinical phenomenon more efficiently, eg, one possible application is to obtain the portal pressure gradient (PPG) to help examine the reliability of hepatic venous pressure gradient (HVPG) as an indirect measure of portal pressure. Moreover, since four to six generations of hepatic vessels, which are sufficient for liver classification analysis, were employed in the model, this study is setting the computational foundation of a potentially handy surgical tool.
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