合成生物学
代谢工程
生化工程
寄主(生物学)
代谢途径
计算机科学
生物技术
计算生物学
生物
酶
工程类
生物化学
生态学
作者
Aaron Cravens,James T. Payne,Christina D. Smolke
标识
DOI:10.1038/s41467-019-09848-w
摘要
Abstract Metabolic engineers endeavor to create a bio-based manufacturing industry using microbes to produce fuels, chemicals, and medicines. Plant natural products (PNPs) are historically challenging to produce and are ubiquitous in medicines, flavors, and fragrances. Engineering PNP pathways into new hosts requires finding or modifying a suitable host to accommodate the pathway, planning and implementing a biosynthetic route to the compound, and discovering or engineering enzymes for missing steps. In this review, we describe recent developments in metabolic engineering at the level of host, pathway, and enzyme, and discuss how the field is approaching ever more complex biosynthetic opportunities.
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