循环肿瘤细胞
微泡
液体活检
医学
肿瘤科
卵巢癌
人口
疾病
活检
癌症
阶段(地层学)
内科学
癌症研究
小RNA
病理
卵巢组织冷冻保存
保持生育能力
生物
基因
转移
古生物学
生物化学
环境卫生
作者
Lydia Giannopoulou,Evi Lianidou
出处
期刊:Advances in Clinical Chemistry
日期:2020-01-01
卷期号:: 13-71
被引量:8
标识
DOI:10.1016/bs.acc.2020.01.001
摘要
Ovarian cancer has the worst survival rate because it is typically diagnosed at advanced stage. Despite treatment, the disease commonly recurs due to chemo-resistance. Liquid biopsy, based on minimally invasive blood tests, has the advantage of following tumor evolution in real time, offering novel insights on cancer prevention and treatment. Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), circulating cell-free microRNAs (cfmiRNAs) and circulating exosomes represent the major components of liquid biopsy. In this chapter, we provide an overview of recent research on CTCs, ctDNA, cfmiRNAs and exosomes in ovarian cancer. We also focus on the clinical value of liquid biopsy in early diagnosis, prognosis, treatment response, as well as screening in the general population.
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