Neurophysiological biomarkers using transcranial magnetic stimulation in Alzheimer’s disease and mild cognitive impairment: A systematic review and meta-analysis

磁刺激 神经科学 神经生理学 谷氨酸的 心理学 神经康复 医学 刺激 内科学 康复 谷氨酸受体 受体
作者
Yu Mimura,Hana Nishida,Shinichiro Nakajima,Sakiko Tsugawa,Shinji Morita,Kazunari Yoshida,Ryosuke Tarumi,Kamiyu Ogyu,Masataka Wada,Shin Kurose,Takahiro Miyazaki,Daniel M. Blumberger,Zafiris J. Daskalakis,Robert Chen,Masaru Mimura,Yoshihiro Noda
出处
期刊:Neuroscience & Biobehavioral Reviews [Elsevier BV]
卷期号:121: 47-59 被引量:69
标识
DOI:10.1016/j.neubiorev.2020.12.003
摘要

Transcranial magnetic stimulation (TMS) is a non-invasive neurophysiological tool that enables the investigation of cortical excitability in the human brain. Paired-pulse TMS paradigms include short- and long-interval intracortical inhibition (SICI/LICI), intracortical facilitation (ICF), and short-latency afferent inhibition (SAI), which can assess neurophysiological functions of GABAergic, glutamatergic, and cholinergic neural circuits, respectively. We conducted the first systematic review and meta-analysis to compare these TMS indices among patients with AD, mild cognitive impairment (MCI), and healthy controls (HC). Our meta-analyses indicated that RMT, SAI, SICI, and LICI were significantly lower in patients with AD, while ICF did not show a difference in patients with AD compared with HC. In patients with MCI, RMT and SAI were significantly lower than in HC. In conclusion, motor cortical excitability was increased, while cholinergic function was decreased in AD and MCI in comparison with HC and patients with AD had decreased GABAergic and glutamatergic functions compared with HC. Our results warrant further studies to differentiate AD, MCI, and HC, employing multimodal TMS neurophysiology.
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