The relationship between Serum ferritin and Osteoporosis

Objective To analyze the difference of serum ferritin among postmenopausal women and men older than 50 years with different bone mass, and to explore the correlation between serum ferritin level and bone mineral density (BMD). Methods Postmenopausal women (n=131) and men (n=65) older than 50 years who received DEXA from September 2018 to February 2019 were enrolled in this study. They were divided into normal (46 cases), osteopenia (68 cases) and osteoporosis (82 cases) groups. Clinical data and biochemical parameters were collected. The level of serum ferritin was detected, and its correlation with BMDwas also determined. Results 1．Compared with normal and osteopenia group, serum ferritin level was significantly increased in osteoporosis group [174.25 (160.85, 210.42) ng/ml vs. 99.50 (91.55, 128.51) ng/ml and 103.36 (93.26, 113.46) ng/ml, χ2=100.573, P<0.05]. 2. The level of serum ferritin was negatively correlated with BMD in hip and lumbar spine (hip r=-0.487, P<0.05; lumbar vertebrae r=-0.531, P<0.05). 3. Multivariate binary logistic regression analysis showed that body weight was the protective factor for osteoporosis (r=0.049, P<0.05), and serum ferritin was the risk factor for osteoporosis (r=-0.018, P<0.05). Conclusion Serum ferritin plays an important role in the prevalence of osteoporosis, which may be a risk factor for osteoporosis. Key words: Bone density; Osteoporosis; Iron overload; Serum ferritin