细胞生物学
细胞粘附
核受体
信号转导
生物
细胞粘附分子
粘附
多细胞生物
雌激素受体
受体
细胞
化学
基因
生物化学
转录因子
遗传学
有机化学
癌症
乳腺癌
作者
Kotaro Sugimoto,Naoki Ichikawa‐Tomikawa,Korehito Kashiwagi,Chihiro Endo,Satoshi Tanaka,Norimasa Sawada,Tetsuya Watabe,Tomohito Higashi,Hideki Chiba
标识
DOI:10.1073/pnas.1913346116
摘要
Significance Cell adhesion is indispensable for multicellular organisms to form cohesive sheets and to serve as tissues and organs. In addition to the adhesive activity, it exhibits the signaling ability to organize a variety of cellular processes. However, the mechanism by which the cell adhesion signaling influences the cellular events, especially on regulation of gene expression, remains obscure. We determine that the cell adhesion signaling originated from the tight-junction protein claudin-6, which targets members of the nuclear receptor superfamily, such as retinoic acid receptor γ and estrogen receptor α, thereby regulating expression of the respective target genes. This signaling provides insight into regulation of nuclear receptor activity by cell adhesion.
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