癌症
生物
癌变
氨酰tRNA合成酶
转移RNA
癌细胞
胰腺癌
计算生物学
氨基酸
癌症研究
生物化学
核糖核酸
遗传学
基因
作者
Zheng Zhou,Bao Sun,Anzheng Nie,Dongsheng Yu,Meng Bian
标识
DOI:10.3389/fcell.2020.599765
摘要
Aminoacyl-tRNA synthetases (ARSs) catalyze the ligation of amino acids to their cognate transfer RNAs (tRNAs), thus playing an important role in protein synthesis. In eukaryotic cells, these enzymes exist in free form or in the form of multi-tRNA synthetase complex (MSC). The latter contains nine cytoplasmic ARSs and three ARS-interacting multifunctional proteins (AIMPs). Normally, ARSs and AIMPs are regarded as housekeeping molecules without additional functions. However, a growing number of studies indicate that ARSs are involved in a variety of physiological and pathological processes, especially tumorigenesis. Here, we introduce the roles of ARSs and AIMPs in certain cancers, such as colon cancer, lung cancer, breast cancer, gastric cancer and pancreatic cancer. Furthermore, we particularly focus on their potential clinical applications in cancer, aiming at providing new insights into the pathogenesis and treatment of cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI