车站3
信号转导
结肠炎
肠系膜淋巴结
炎症性肠病
医学
分泌物
溃疡性结肠炎
免疫学
生物
细胞生物学
疾病
免疫系统
内科学
作者
Hui-Min Lai,Zhengbiao Yang,Zhaohuan Lou,Feng Li,Feng Xie,Wei Pan,Cong Xu,Lili Zhang,Sheng Zhang,Li-Jiang Zhang,Min-Cong Huang
标识
DOI:10.3389/fphar.2021.615506
摘要
Ulcerative colitis (UC) is a chronic, idiopathic and relapsing inflammatory disease of the gastrointestinal tract that has a prolonged disease duration. Lindera aggregata (Sims) Kosterm. is a traditional Chinese herb which has been used to treat gastrointestinal diseases for thousand years. However, there are few reports about the application of L. aggregata in the treatment of UC at present. Herein, we investigated the therapeutic effect of the root extract of L. aggregata (LREE) against UC and explored its underlying mechanisms based on IL-6 signaling pathway and the balance of T helper (Th) 17 and regulatory T (Treg) cells. Results showed that LREE could not only decrease the production and secretion of IL-6, but also could inhibit the signal transduction of IL-6/STAT3 signaling pathway. Moreover, LREE could significantly inhibit the differentiation of CD4 + T cells to Th17 cells in vitro and decrease the proportion of Th17 cells in mesenteric lymph nodes (MLNs) of model mice in vivo . Besides, LREE could also alleviate the disease symptoms, reduce intestinal permeability and improve histopathological changes of colitis model mice. Together, LREE can significantly inhibit the production and secretion of IL-6, regulate IL-6/STAT3 signal transduction, and modulate the balance of Th17 and Treg cells and effectively attenuate UC.
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