抗菌剂
肺炎
冠状病毒
微生物学
抗生素耐药性
抗生素
2019年冠状病毒病(COVID-19)
医学
生物
病毒学
传染病(医学专业)
疾病
内科学
病理
作者
Ãngel Serrano‐Aroca,Kazuo Takayama,Alberto Tuñón-Molina,Murat Seyran,Sk. Sarif Hassan,Pabitra Pal Choudhury,Vladimir N. Uversky,Kenneth Lundström,Parise Adadi,Giorgio Palù,Alaa A. A. Aljabali,Gaurav Chauhan,Ramesh Kandimalla,Murtaza M. Tambuwala,Amos Lal,Tarek Mohamed Abd El‐Aziz,Samendra P. Sherchan,Debmalya Barh,Elrashdy M. Redwan,Nicolás G. Bazán,Yogendra Kumar Mishra,Bruce D. Uhal,Adam Brufsky
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-04-07
卷期号:15 (5): 8069-8086
被引量:151
标识
DOI:10.1021/acsnano.1c00629
摘要
Therapeutic options for the highly pathogenic human severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the current pandemic coronavirus disease (COVID-19) are urgently needed. COVID-19 is associated with viral pneumonia and acute respiratory distress syndrome causing significant morbidity and mortality. The proposed treatments for COVID-19 have shown little or no effect in the clinic so far. Additionally, bacterial and fungal pathogens contribute to the SARS-CoV-2-mediated pneumonia disease complex. The antibiotic resistance in pneumonia treatment is increasing at an alarming rate. Therefore, carbon-based nanomaterials (CBNs), such as fullerene, carbon dots, graphene, and their derivatives constitute a promising alternative due to their wide-spectrum antimicrobial activity, biocompatibility, biodegradability, and capacity to induce tissue regeneration. Furthermore, the antimicrobial mode of action is mainly physical (e.g., membrane distortion), characterized by a low risk of antimicrobial resistance. In this Review, we evaluated the literature on the antiviral activity and broad-spectrum antimicrobial properties of CBNs. CBNs had antiviral activity against 13 enveloped positive-sense single-stranded RNA viruses, including SARS-CoV-2. CBNs with low or no toxicity to humans are promising therapeutics against the COVID-19 pneumonia complex with other viruses, bacteria, and fungi, including those that are multidrug-resistant.
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