光学
材料科学
激光器
荧光寿命成像显微镜
二次谐波产生
拉曼散射
飞秒
吲哚青绿
烧蚀
激光烧蚀
光电子学
荧光
物理
拉曼光谱
工程类
航空航天工程
作者
Chenting Lai,Bernhard Messerschmidt,Sven Flämig,Karl Reichwald,Hyeonsoo Bae,Matteo Calvarese,Tobias Meyer,Michael Schmitt,Franziska Hoffmann,Orlando Guntinas‐Lichius,Jürgen Popp
摘要
Here, we report a new handheld endoscopic system for nonlinear multimodal imaging of the head and neck region. It has a long rigid endomicroscopic probe with two versions (0° and 45° bended tip), connecting with a compact scan-head of approx. 10×12×6 cm3 size. The rigid probe is 6 mm in diameter and 24 cm long and allows diffraction-limited multiphoton imaging of tissue with at least 430 μm field of view and sub-micron resolution. The signals of Coherent anti-Stokes Raman Scattering (CARS), second harmonic generation (SHG), and two-photon excited fluorescence (TPEF) are collected by a non-descanned detection path in the scan-head, and the fluorescence of Indocyanine green (ICG) labeled lesions is detected by a confocal descanned configuration. Furthermore, this system is capable of guiding high-power femtosecond laser pulses for tissue ablation without the risk of damaging optical glass components.
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