舍瓦内拉
微生物
化学
细菌
电子转移
生物修复
金属
水溶液中的金属离子
体内
戒毒(替代医学)
微生物燃料电池
基质(水族馆)
生物化学
生物物理学
生物
生物技术
生态学
光化学
有机化学
物理化学
病理
阳极
替代医学
医学
遗传学
电极
作者
Yu Zhang,Ting Pan,Chu‐Xin Li,Di‐Wei Zheng,Yunxia Sun,Xian‐Zheng Zhang
出处
期刊:Nano Letters
[American Chemical Society]
日期:2022-06-28
卷期号:22 (13): 5575-5583
被引量:12
标识
DOI:10.1021/acs.nanolett.2c01907
摘要
Synthetic biology has promoted the development of microbial therapy, but the scope of applicable microbial species is limited and transgenic microorganisms also display safety risks for in vivo applications. Interestingly, symbiotic microorganisms in nature can achieve functional updates by metabolic cooperation. Here, we report on a nongenetic method for engineering microorganisms to construct a heavy metal ion reduction system, which was prepared by linking Shewanella oneidensis MR-1 (SO) and Lactobacillus rhamnosus GG (LGG). SO could reduce metal ions but is limited by finite substrates in vivo. LGG could metabolize glucose to lactate as a substrate for SO, promoting extracellular electron transfer by SO and heavy metal ion reduction. Meanwhile, SO could generate electron donor cytochrome C to promote metabolism of LGG, forming metabolic synergy and circulation between these two bacteria. The SO-LGG system shows splendid ability to remove heavy metal ions and inflammatory modulation in acute or chronic heavy metal poisoning.
科研通智能强力驱动
Strongly Powered by AbleSci AI