Euler-Lagrange numerical simulation of improved magnetic drug delivery in a three-dimensional CT-based carotid artery bifurcation

机械 有限元法 物理 层流 材料科学 生物医学工程 经典力学 医学 热力学
作者
Hiwa Aryan,Borhan Beigzadeh,Majid Siavashi
出处
期刊:Computer Methods and Programs in Biomedicine [Elsevier BV]
卷期号:219: 106778-106778 被引量:24
标识
DOI:10.1016/j.cmpb.2022.106778
摘要

Magnetic drug targeting (MDT) is a promising method to improve the therapy efficiency for cardiovascular diseases (CVDs) and cancers. In MDT, therapeutic agents are bonded to superparamagnetic iron oxide nanoparticle (SPION) cores and then are guided toward the damaged tissue through a magnetic field. Fundamentally, it's vital to steer the SPIONs to the desired location to increase the capture efficiency at the target lesion. Hence, the present study aims to enhance the drug delivery to the desired branch in a carotid bifurcation. Besides, it is tried to decrement the particles' entry to the unwanted outlet by using four different magnet configurations (with a maximum magnetic flux density of 0.4 T) implanted adjacent to the artery wall. Also, the effect of particles' diameter -ranging from 200 nm to 2 µm- on the drug delivery performance is studied in the four cases.The Eulerian-Lagrangian approach with one-way coupling is employed for numerical simulation of the problem using the finite element method (FEM). The dominant forces acting on particles are drag and magnetophoretic. A computed tomography (CT) model of the carotid bifurcation is adopted to have a 3D realistic geometry. The blood flow is considered to be laminar, incompressible, pulsatile, and non-Newtonian. Boundary conditions are applied using the three-element Windkessel equation.Results are presented in terms of velocity, pressure, magnetic field flux density, wall shear stress, and streamlines. Also, the number of particles in each direction is presented for the four studied cases. The results show that using proper magnets configurations makes it possible to guide more particles to the desired branch (up to 4%) while preventing particles from entering the unwanted branch (up to 13%). By defining connectivity between oscillatory shear index (OSI) value and magnetic drug delivery efficacy, it becomes clear that places with lower OSI values are more proper to place the magnets than areas with higher OSI values.It was observed that increasing the diameter of particles does not necessarily result in a higher drug delivery efficiency. The configuration of the magnets and the size of particles are the main affecting parameters that should be chosen precisely to meet the most efficient drug delivery performance. Magnetic drug targeting (MDT) is a promising method to improve the therapy efficiency for cardiovascular diseases (CVDs) and cancers. Fundamentally, it's vital to steer the superparamagnetic iron oxide nanoparticles (SPIONs) to the target lesion location to increase the capture efficiency. Hence, the present study aims to enhance the drug delivery to the desired branch in a 3D carotid bifurcation. Besides, it is tried to decrement the particles' entry to the unwanted outlet by using four different magnet configurations implanted adjacent to the artery wall. The Eulerian-Lagrangian approach with one-way coupling is employed for numerical simulation of the problem using the finite element method (FEM). The dominant forces acting on particles are drag and magnetophoretic. The blood flow is laminar, incompressible, pulsatile, and non-Newtonian. The results show that it is possible to guide more particles to the desired branch (up to 4%) while preventing particles from entering the unwanted branch (up to 13%). By defining connectivity between oscillatory shear index (OSI) value and magnetic drug delivery efficacy, it becomes clear that places with lower OSI values are more proper to place the magnets than areas with higher OSI values.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
可靠的如之完成签到,获得积分10
2秒前
专注棒棒糖完成签到 ,获得积分10
2秒前
2秒前
Lily发布了新的文献求助10
2秒前
3秒前
YZQ发布了新的文献求助10
4秒前
黑咖啡完成签到,获得积分10
4秒前
Liufgui应助可靠的如之采纳,获得10
6秒前
科研通AI2S应助阿俊采纳,获得10
7秒前
8秒前
10秒前
12秒前
12秒前
JamesPei应助YZQ采纳,获得10
13秒前
Orange应助邪恶花生米采纳,获得10
13秒前
weijie发布了新的文献求助10
13秒前
hf完成签到,获得积分10
13秒前
13秒前
15秒前
量子星尘发布了新的文献求助30
16秒前
硅负极完成签到,获得积分10
16秒前
zzt发布了新的文献求助10
16秒前
17秒前
Dr.Yang发布了新的文献求助10
18秒前
20秒前
刻苦的秋柔完成签到,获得积分10
22秒前
意大利种马完成签到,获得积分20
23秒前
orixero应助写得出发的中采纳,获得10
25秒前
刘雨森完成签到 ,获得积分10
26秒前
坦率白萱应助littleblack采纳,获得10
27秒前
香蕉觅云应助意大利种马采纳,获得10
28秒前
ZS完成签到,获得积分10
28秒前
帅哥的事情少管完成签到,获得积分10
29秒前
littlestone完成签到,获得积分10
30秒前
NexusExplorer应助ShuXU采纳,获得10
32秒前
果果完成签到,获得积分10
32秒前
项绝义完成签到,获得积分10
33秒前
33秒前
空古悠浪发布了新的文献求助20
33秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988920
求助须知:如何正确求助?哪些是违规求助? 3531290
关于积分的说明 11253247
捐赠科研通 3269903
什么是DOI,文献DOI怎么找? 1804830
邀请新用户注册赠送积分活动 882027
科研通“疑难数据库(出版商)”最低求助积分说明 809052