抑制性突触后电位
先天性淋巴细胞
突触
细胞生物学
神经科学
生物
免疫学
化学
先天免疫系统
免疫系统
作者
Jerika J. Barron,Nicholas M. Mroz,Sunrae E. Taloma,Madelene W. Dahlgren,Jorge F. Ortiz-Carpena,Leah C. Dorman,Ilia D. Vainchtein,Caroline C. Escoubas,Ari B. Molofsky,Anna V. Molofsky
标识
DOI:10.1101/2023.03.16.532850
摘要
Abstract The innate immune system plays essential roles in brain synaptic development, and immune dysregulation is implicated in neurodevelopmental diseases. Here we show that a subset of innate lymphocytes (group 2 innate lymphoid cells, ILC2s) is required for cortical inhibitory synapse maturation and adult social behavior. ILC2s expanded in the developing meninges and produced a surge of their canonical cytokine Interleukin-13 (IL-13) between postnatal days 5-15. Loss of ILC2s decreased cortical inhibitory synapse numbers in the postnatal period where as ILC2 transplant was sufficient to increase inhibitory synapse numbers. Deletion of the IL-4/IL-13 receptor ( Il4ra ) from inhibitory neurons phenocopied the reduction inhibitory synapses. Both ILC2 deficient and neuronal Il4ra deficient animals had similar and selective impairments in adult social behavior. These data define a type 2 immune circuit in early life that shapes adult brain function. One sentence summary Type 2 innate lymphoid cells and Interleukin-13 promote inhibitory synapse development.
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