Single‐step genome‐wide association study reveals candidate genes for body mass index trait in Yunong‐black pigs

生物 候选基因 全基因组关联研究 特质 遗传学 数量性状位点 基因 遗传关联 基因组 体质指数 计算生物学 单核苷酸多态性 基因型 内分泌学 计算机科学 程序设计语言
作者
Ziyi Wu,Tengfei Dou,Jiahao Wu,Liyao Bai,Zhang Yong-qian,Shengyuan Zan,Songbai Yang,Hao Zhou,Jinyi Han,Xuelei Han,Ruimin Qiao,Kejun Wang,Feng Yang,Xinjian Li,Xiuling Li
出处
期刊:Animal Genetics [Wiley]
卷期号:56 (1)
标识
DOI:10.1111/age.13501
摘要

Body mass index (BMI) can serve as a reasonable indicator of overall body fat content in pigs. This study aimed to identify underlying variants and candidate genes associated with BMI in Yunong-black pigs. A single-step genome-wide association analysis (GWAS) was performed on 1405 BMI records and 924 Yunong-black pigs genotyped using a 50 K SNP Chip. De-regressed estimated breeding values were taken as the response variable in the GWAS. The estimated heritability for BMI was 0.157. Nine significant regions were associated with BMI, accounting for 12.828% of genetic variance, with the highest region explaining 1.969% of the genetic variance. Linkage disequilibrium analysis of the nine significant regions revealed that SNPs in six single-step GWAS-identified genomic regions were all located in the linkage disequilibrium blocks. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses of the 29 protein-coding genes annotated to these regions revealed that FABP2, a key gene associated with BMI in human, was enriched in the fatty acid binding term and the fat digestion and absorption pathway. This study provides a better insight into the genetic architecture of the BMI trait, and offers potential molecular markers for the breeding of Yunong-black pigs.

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