Skin sympathetic nerve activity during unprovoked syncope in an ambulatory patient with postural orthostatic tachycardia syndrome

Cardioneuroablation has gained increasing importance in managing syncope. However, there is no data on sympathetic nerve activity (SNA) in ambulatory patients with unprovoked syncope. We performed a prospective study on 41 participants (38±13 years old, 38 women, 2 men, and 1 transgender man) with postural orthostatic tachycardia syndrome (POTS) and at least one episode of syncope or presyncope in their medical history, approved by the Institutional Review Board of the Cedars-Sinai Medical Center to test the hypothesis that large SKNA bursts precede the onset of syncope. All participants underwent 1-5 days of ambulatory recording using a Faros 180 electrocardiogram (ECG) Monitor (Bittium, Oulu, Finland). 1 Liu X. Rosenberg C. Ricafrente J. et al. Using an ambulatory electrocardiogram monitor to record skin sympathetic nerve activity. Heart Rhythm. 2022; 19: 330-331 Google Scholar Participants were instructed to press the marker button and record in diaries whenever they experienced symptoms. The nerve activity was analyzed using LabChart 8 Pro (ADInstruments Inc, Colorado Springs, USA). One-way ANOVA was used to compare multiple groups using IBM SPSS Statistics 24 (SPSS Inc, Chicago, IL, USA). Two-sided p ≤ .05 was considered significant.