Association between the triglyceride glucose index and cognitive impairment and dementia: a meta-analysis

痴呆 医学 认知 认知障碍 科克伦图书馆 内科学 荟萃分析 索引(排版) 精神科 疾病 万维网 计算机科学
作者
Huan Wang,Ling Qin,Yifan Wu,Mingjie Zhang
出处
期刊:Frontiers in Aging Neuroscience [Frontiers Media]
卷期号:15 被引量:8
标识
DOI:10.3389/fnagi.2023.1278730
摘要

Background The triglyceride and glucose (TyG) index is an alternative index of insulin resistance (IR). We aimed to clarify the relationship between the TyG index and cognitive impairment and dementia. Methods We conducted a comprehensive search of the PubMed, Cochrane Library, and Embase databases until February 2023 to identify relevant studies. Random-effects models were used to pool effect sizes, and the Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to assess the quality of the evidence. Results Ten studies were included, with seven of which investigated the relationship between the TyG index and cognitive impairment and three exploring the association between the TyG index and dementia. When the TyG index was described as a categorical variable, it was positively associated with the risk of cognitive impairment (OR = 2.32; 95% CI 1.39–3.87) and dementia (OR = 1.14, 95% CI 1.12–1.16). The association of the TyG index with the risk of cognitive impairment (OR = 3.39, 95% CI 1.67–6.84) and dementia (OR = 1.37, 95% CI 1.03–1.83) remained significant for per 1 unit increment in the TyG index. The GRADE assessment indicated a very low certainty for cognitive impairment. Low certainty and moderate certainty were observed for dementia when the TyG index was analyzed as a categorical variable and as a continuous variable, respectively. Conclusion The TyG index is associated with an increased risk of cognitive impairment and dementia. Further prospective research is warranted to confirm these findings. Systematic review registration: https://www.crd.york.ac.uk/ , Protocol registration number: CRD42023388028.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Fan完成签到,获得积分10
刚刚
yabocai发布了新的文献求助10
刚刚
1秒前
黄杰完成签到 ,获得积分10
1秒前
未名白发布了新的文献求助10
2秒前
qqqyy完成签到,获得积分10
4秒前
4秒前
lzh完成签到,获得积分20
4秒前
文风杰采完成签到,获得积分10
4秒前
时冬冬完成签到,获得积分0
4秒前
与我常在发布了新的文献求助20
4秒前
爆米花应助灯塔水母采纳,获得10
4秒前
常大有完成签到,获得积分10
4秒前
安静一曲完成签到 ,获得积分10
5秒前
HJJHJH完成签到,获得积分10
5秒前
满唐完成签到 ,获得积分10
6秒前
Xzx1995完成签到 ,获得积分10
6秒前
寒冷书竹完成签到,获得积分20
6秒前
曾曾完成签到,获得积分10
7秒前
7秒前
lvyan完成签到,获得积分10
7秒前
贫穷的塔姆完成签到,获得积分10
7秒前
危机的土豆完成签到,获得积分20
7秒前
粗犷的凌兰完成签到,获得积分10
8秒前
SciGPT应助zhizhiman采纳,获得10
8秒前
爱笑的曼易完成签到,获得积分10
8秒前
三木埃尔完成签到,获得积分10
8秒前
景绝义完成签到,获得积分10
9秒前
迷你的百川完成签到,获得积分10
9秒前
10秒前
坚定的迎波完成签到,获得积分10
10秒前
不知道完成签到,获得积分10
10秒前
英俊绝义完成签到 ,获得积分10
11秒前
min20210429完成签到,获得积分10
11秒前
YXH完成签到,获得积分10
12秒前
cadnash发布了新的文献求助10
12秒前
有梦想的人不睡觉完成签到,获得积分10
12秒前
roselau完成签到,获得积分10
12秒前
救救孩子救救孩子完成签到,获得积分10
12秒前
HJJHJH发布了新的文献求助20
13秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
Immigrant Incorporation in East Asian Democracies 600
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3968637
求助须知:如何正确求助?哪些是违规求助? 3513552
关于积分的说明 11168493
捐赠科研通 3248935
什么是DOI,文献DOI怎么找? 1794554
邀请新用户注册赠送积分活动 875188
科研通“疑难数据库(出版商)”最低求助积分说明 804691