Association between the triglyceride glucose index and cognitive impairment and dementia: a meta-analysis

痴呆 医学 认知 认知障碍 科克伦图书馆 内科学 荟萃分析 索引(排版) 精神科 疾病 万维网 计算机科学
作者
Huan Wang,Ling Qin,Yifan Wu,Mingjie Zhang
出处
期刊:Frontiers in Aging Neuroscience [Frontiers Media]
卷期号:15 被引量:8
标识
DOI:10.3389/fnagi.2023.1278730
摘要

Background The triglyceride and glucose (TyG) index is an alternative index of insulin resistance (IR). We aimed to clarify the relationship between the TyG index and cognitive impairment and dementia. Methods We conducted a comprehensive search of the PubMed, Cochrane Library, and Embase databases until February 2023 to identify relevant studies. Random-effects models were used to pool effect sizes, and the Grading of Recommendations Assessment, Development, and Evaluation system (GRADE) was used to assess the quality of the evidence. Results Ten studies were included, with seven of which investigated the relationship between the TyG index and cognitive impairment and three exploring the association between the TyG index and dementia. When the TyG index was described as a categorical variable, it was positively associated with the risk of cognitive impairment (OR = 2.32; 95% CI 1.39–3.87) and dementia (OR = 1.14, 95% CI 1.12–1.16). The association of the TyG index with the risk of cognitive impairment (OR = 3.39, 95% CI 1.67–6.84) and dementia (OR = 1.37, 95% CI 1.03–1.83) remained significant for per 1 unit increment in the TyG index. The GRADE assessment indicated a very low certainty for cognitive impairment. Low certainty and moderate certainty were observed for dementia when the TyG index was analyzed as a categorical variable and as a continuous variable, respectively. Conclusion The TyG index is associated with an increased risk of cognitive impairment and dementia. Further prospective research is warranted to confirm these findings. Systematic review registration: https://www.crd.york.ac.uk/ , Protocol registration number: CRD42023388028.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
圈圈叉叉发布了新的文献求助10
1秒前
redking发布了新的文献求助10
1秒前
缥缈剑愁发布了新的文献求助10
2秒前
CodeCraft应助圆蓬蓬采纳,获得10
2秒前
zhaoyuli完成签到,获得积分10
2秒前
啊啊发布了新的文献求助10
2秒前
2秒前
ZH发布了新的文献求助10
4秒前
研友_VZG7GZ应助Endeavor采纳,获得10
4秒前
warden完成签到 ,获得积分10
4秒前
科研通AI2S应助sisyphus_yy采纳,获得10
5秒前
施天问发布了新的文献求助10
5秒前
7秒前
Singularity应助内向寒云采纳,获得10
7秒前
dd完成签到 ,获得积分10
7秒前
8秒前
Miracle发布了新的文献求助10
9秒前
开花完成签到,获得积分10
9秒前
量子星尘发布了新的文献求助10
10秒前
11秒前
redking完成签到,获得积分10
11秒前
lingquanmeng完成签到,获得积分10
12秒前
12秒前
羽生发布了新的文献求助10
12秒前
隐形曼青应助miumiu采纳,获得10
13秒前
beckham发布了新的文献求助10
14秒前
施天问完成签到,获得积分10
15秒前
uu发布了新的文献求助10
15秒前
16秒前
16秒前
16秒前
小蘑菇应助Miracle采纳,获得10
16秒前
轩轩轩轩完成签到 ,获得积分10
17秒前
17秒前
18秒前
litao完成签到,获得积分10
19秒前
乐乐应助九千七采纳,获得10
21秒前
梁三柏应助makabaka采纳,获得10
21秒前
22秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3975755
求助须知:如何正确求助?哪些是违规求助? 3520108
关于积分的说明 11200829
捐赠科研通 3256492
什么是DOI,文献DOI怎么找? 1798298
邀请新用户注册赠送积分活动 877509
科研通“疑难数据库(出版商)”最低求助积分说明 806403