酵母多糖
敏化
内脏痛
机械敏感通道
内科学
医学
免疫学
生物
伤害
生物化学
体外
受体
离子通道
作者
Tiantian Guo,Jia Liu,Longtu Chen,Zichao Bian,Guoan Zheng,Bin Feng
出处
期刊:American Journal of Physiology-gastrointestinal and Liver Physiology
[American Physiological Society]
日期:2024-02-01
卷期号:326 (2): G133-G146
被引量:2
标识
DOI:10.1152/ajpgi.00081.2023
摘要
We used high-throughput GCaMP6f recordings to study 2,275 mechanosensitive colorectal afferents in mice. Our results revealed significant sex differences in the zymosan-induced behavioral visceral hypersensitivity, which were present in male but not female mice. Male mice also showed sensitization of colorectal afferents in the thoracolumbar pathway, whereas female mice did not. These findings highlight sex differences in sensory neural anatomy and function of the colorectum, with implications for sex-specific therapies for treating visceral pain.
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