泄漏(经济)
药品
纳米颗粒
胶体金
纳米技术
材料科学
粒径
化学工程
生物物理学
药理学
医学
经济
宏观经济学
生物
工程类
作者
Yun Hao Feng,Wei Guo,Xiaobin Li,Jiahui Liu,Vahideh Nosrati-Siahmazgi,Maryam Toolabi,Wen Min Fei,Yong Cui,Bo Zhi Chen,Mohammad-Ali Shahbazi,Li Juan Zhang,Can Yang Zhang,Xin Dong Guo
标识
DOI:10.1016/j.ces.2023.118715
摘要
Nanovesicle has been extensively investigated and widely used in biomedical applications. However, the premature leakage of water-soluble drugs from nanovesicle seriously limits the further clinical use. It’s of great significance to develop effective strategy for leakage inhibition. Herein, we explored effective strategies to prevent drug leakage through coarse-grained molecular simulations. We investigated the influences of doping of cholesteryl hemisuccinate and gold nanoparticles on the morphology and structure of nanovesicle. We found that cholesteryl hemisuccinate can effectively improve the hole defects in the hydrophobic layer to adjust the drug diffusion performance. Then, we studied the effects of particle size, concentration, and surface chemical properties of gold nanoparticles on the drug leakage of nanovesicle. We further verified that the “physical cross-linking” of gold nanoparticles led to more drugs leaking from the nanovesicle cavity. With surface modification, the side effects of “physical cross-linking” were improved with the enhanced dispersion of gold nanoparticles.
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