Thalamic network under wakefulness after sleep onset and its coupling with daytime fatigue in insomnia disorder: An EEG-fMRI study

清醒 失眠症 脑电图 心理学 小脑 功能磁共振成像 丘脑 睡眠开始 神经影像学 神经科学 听力学 医学 精神科
作者
Yupeng Guo,Yun Chen,Yan Shao,Sifan Hu,Guangyuan Zou,Jie Chen,Yuezhen Li,Xuejiao Gao,Jiayi Liu,Ping Yao,Shuqin Zhou,Jing Xu,Jia‐Hong Gao,Qihong Zou,Hongqiang Sun
出处
期刊:Journal of Affective Disorders [Elsevier BV]
卷期号:334: 92-99 被引量:6
标识
DOI:10.1016/j.jad.2023.04.100
摘要

Fatigue is the most common daytime impairment of insomnia disorder (ID). Thalamus is acknowledged as the key brain region closely associated with fatigue. However, the thalamus-based neurobiological mechanisms of fatigue in patients with ID remain unknown. Forty-two ID patients and twenty-eight well-matched healthy controls (HCs) underwent simultaneous electroencephalography––functional magnetic resonance imaging. We calculated the functional connectivity (FC) between the thalamic seed and each voxel across the whole brain in two conditions of wakefulness––after sleep onset (WASO) and before sleep onset. A linear mixed effect model was used to determine the condition effect of the thalamic FC. The correlation between daytime fatigue and the thalamic connectivity was explored. After sleep onset, the connectivity with the bilateral thalamus was increased in the cerebellar and cortical regions. Compared with HCs, ID patients showed significantly lower FC between left thalamus and left cerebellum under the WASO condition. Furthermore, thalamic connectivity with cerebellum under the WASO condition was negatively correlated with Fatigue Severity Scale scores in the pooled sample. These findings contribute to an emerging framework that reveals the link between insomnia-related daytime fatigue and the altered thalamic network after sleep onset, further highlighting the possibility that this neural pathway is a therapeutic target for meaningfully mitigating fatigue.
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