医学
抗生素
药代动力学
哌拉西林/他唑巴坦
哌拉西林
克林霉素
他唑巴坦
甲硝唑
胸腔积液
阿莫西林
胸膜液
内科学
微生物学
抗生素耐药性
亚胺培南
铜绿假单胞菌
细菌
生物
遗传学
作者
David Arnold,Liam Read,Oliver Waddington,Fergus Hamilton,Sonia Patole,Jessica Hughes,Alice Milne,Alan Noel,Mark Bayliss,Nick Maskell,Alasdair MacGowan
出处
期刊:Thorax
[BMJ]
日期:2024-07-04
卷期号:: thorax-220402
标识
DOI:10.1136/thorax-2023-220402
摘要
Pleural infection is usually treated with empirical broad-spectrum antibiotics, but limited data exist on their penetrance into the infected pleural space. We performed a pharmacokinetic study analysing the concentration of five intravenous antibiotics across 146 separate time points in 35 patients (amoxicillin, metronidazole, piperacillin-tazobactam, clindamycin and cotrimoxazole). All antibiotics tested, apart from co-trimoxazole, reach pleural fluid levels equivalent to levels within the blood and well above the relevant minimum inhibitory concentrations. The results demonstrate that concerns about the penetration of commonly used antibiotics, apart from co-trimoxazole, into the infected pleural space are unfounded.
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