棕榈酸
地塞米松
类风湿性关节炎
白蛋白
医学
药理学
内科学
血清白蛋白
人白蛋白
化学
内分泌学
生物化学
脂肪酸
作者
Yu Zhang,Xueru Zhou,Zijun Wang,Mengying Wu,Qi Chen,Zhirong Zhang,Xun Sun,Tao Gong
标识
DOI:10.1016/j.xphs.2024.07.013
摘要
Rheumatoid arthritis (RA) is a chronic inflammatory joint condition characterized by symmetric, erosive synovitis leading to cartilage erosion and significant disability. Macrophages, pivotal in disease progression, release pro-inflammatory factors upon activation. We developed a nanoparticle delivery system (DXP-PSA NPs), based on palmitic acid modified human serum albumin (PSA), to deliver dexamethasone palmitate (DXP) directly to sites of inflammation, enhancing treatment effectiveness and minimizing possible side effects. The system actively targets scavenger receptor-A on activated macrophages, achieving selective accumulation at inflamed joints. In vitro effect and preliminary targeting abilities were investigated on LPS-activated RAW264.7 cells. The in vivo efficacy and safety were evaluated and compared side to side with commercially available lipid emulsion Limethason® in an advanced adjuvant-induced arthritis rat model. DXP-PSA NPs offer a novel approach to RA treatment and presents promising prospects for clinical translation.
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