神经科学
可塑性
神经可塑性
神经元回路
生物
发育可塑性
运动前神经元活动
心理学
热力学
物理
作者
Travis E. Faust,Benjamin A. Devlin,Isabella Farhy-Tselnicker,Austin Ferro,Maggie Postolache,Wendy Xin
标识
DOI:10.1523/jneurosci.1208-24.2024
摘要
The brain is a highly adaptable organ that is molded by experience throughout life. Although the field of neuroscience has historically focused on intrinsic neuronal mechanisms of plasticity, there is growing evidence that multiple glial populations regulate the timing and extent of neuronal plasticity, particularly over the course of development. This review highlights recent discoveries on the role of glial cells in the establishment of cortical circuits and the regulation of experience-dependent neuronal plasticity during critical periods of neurodevelopment. These studies provide strong evidence that neuronal circuit maturation and plasticity are non-cell autonomous processes that require both glial–neuronal and glial–glial cross talk to proceed. We conclude by discussing open questions that will continue to guide research in this nascent field.
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