溃疡性结肠炎
压电1
结肠炎
癌症研究
医学
细胞生物学
化学
免疫学
生物
病理
生物化学
疾病
机械敏感通道
离子通道
受体
作者
Jiejie Zhu,Yumei Wu,Luyao Zhang,Bingqing Bai,Wei Han,Hua Wang,Mei Qiao
标识
DOI:10.1016/j.freeradbiomed.2024.08.039
摘要
Ferroptosis, a recently discovered form of regulated cell death, has been implicated in the development of ulcerative colitis (UC). While Piezo1's role in inducing ferroptosis in chondrocytes and pulmonary endothelial cells is documented, its regulatory function in ferroptosis and intestinal epithelial cells in UC remains unclear. To address this, colonic tissue samples from patients with UC were examined, and specific intestinal epithelial Piezo1-deficient (Piezo1
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