Obesity is an independent risk factor for cancer development following diagnosis of dermatomyositis

医学 内科学 皮肌炎 优势比 肥胖 癌症 危险系数 风险因素 人口 乳腺癌 置信区间 结直肠癌 体质指数 肿瘤科 环境卫生
作者
Astia Allenzara,Nakisa B. Sadeghi,Carolina Álvarez,Steve Maczuga,Matthew Helm,Nancy J. Olsen,Amanda E. Nelson,Galen Foulke
出处
期刊:Seminars in Arthritis and Rheumatism [Elsevier BV]
卷期号:64: 152283-152283 被引量:1
标识
DOI:10.1016/j.semarthrit.2023.152283
摘要

Patients with dermatomyositis (DM) are at an increased risk of cancer development, especially around the time of diagnosis of DM. Obesity is also a risk factor in the general population for cancer development. This study aimed to assess the association between cancer in DM patients with and without obesity as defined by ICD code and BMI data. In this analysis of patients with DM, logistic regression modeling of the odds of cancer outcome was performed for patients with DM and obesity compared to those without obesity, adjusted for age and sex. A total of 12,722 patients with DM were identified, of whom 6,055 had available BMI data. DM patients who were coded obese at any point had significantly higher odds 1.98 (95 % Confidence interval (CI) 1.70, 2.30) of a subsequent cancer diagnosis. This association was also found in the subgroup analysis with available BMI where patients with obesity (BMI ≥30 kg/m2) had an increased odds of cancer 1.23 (1.02, 1.49) when compared to patients with BMI <30 kg/m2 with DM. In time to event analysis any obesity code was associated with a 16 % increased hazard of cancer (adjusted hazard ratio 1.16 [95 % CI 1.02, 1.31]). Overall, the most frequent type of cancer was breast cancer, however patients with DM and obesity had higher frequencies of lymphoma, colorectal, melanoma, uterine, renal cancers compared to patients with DM without obesity.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
2秒前
Zhang完成签到,获得积分10
3秒前
4秒前
4秒前
5秒前
6秒前
圆锥香蕉给ZEcholy的求助进行了留言
7秒前
jisujun发布了新的文献求助10
7秒前
李小宁发布了新的文献求助10
7秒前
10秒前
Stroeve发布了新的文献求助10
11秒前
欧阳月空完成签到,获得积分10
11秒前
11秒前
星辰大海应助李小宁采纳,获得10
12秒前
段一帆发布了新的文献求助10
12秒前
冷艳的姿发布了新的文献求助10
12秒前
13秒前
FIN应助小小采纳,获得30
13秒前
领导范儿应助su采纳,获得10
14秒前
Candy发布了新的文献求助10
14秒前
Rondab应助xiaosu采纳,获得10
15秒前
CodeCraft应助LJJ采纳,获得10
16秒前
16秒前
SYLH应助科研通管家采纳,获得20
17秒前
所所应助科研通管家采纳,获得10
17秒前
科研通AI5应助科研通管家采纳,获得10
17秒前
张金蝶完成签到,获得积分10
17秒前
搜集达人应助科研通管家采纳,获得10
18秒前
CAOHOU应助科研通管家采纳,获得10
18秒前
丘比特应助科研通管家采纳,获得10
18秒前
CAOHOU应助科研通管家采纳,获得10
18秒前
赘婿应助科研通管家采纳,获得10
18秒前
量子星尘发布了新的文献求助30
18秒前
SYLH应助科研通管家采纳,获得20
18秒前
18秒前
18秒前
18秒前
CAOHOU应助科研通管家采纳,获得10
18秒前
Lyuhng+1完成签到 ,获得积分10
19秒前
大个应助十九岁的时差采纳,获得10
20秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989334
求助须知:如何正确求助?哪些是违规求助? 3531428
关于积分的说明 11253936
捐赠科研通 3270119
什么是DOI,文献DOI怎么找? 1804887
邀请新用户注册赠送积分活动 882087
科研通“疑难数据库(出版商)”最低求助积分说明 809173