神经保护
医学
疾病
多巴胺能
神经科学
药理学
精神科
多巴胺
心理学
内科学
作者
Camilla Nicolucci,Milenna Padovani,Fernanda de Castro Rodrigues,Laura Nagy Fritsch,Ana Cristina Santos,Denise Gonçalves Priolli,Juliana Mozer Sciani
标识
DOI:10.1080/14786419.2023.2275275
摘要
AbstractGiven the current increase in mental and neurological disorders, there is an urgent need to develop alternative treatments for patients. Flavonoids exhibit diverse biological activities, including antioxidant, anti-inflammatory and neuroprotective, and has been considered potential therapies for central nervous system diseases, such as Alzheimer’s disease, Parkinson’s disease, drug addiction, and stroke. Studies have shown that flavonoids protect neurons from oxidative stress, reduce inflammation, improve brain blood flow and enhance cognitive function. Moreover, its modulation of neurotransmission, such as GABAergic, dopaminergic, serotoninergic, and noradrenergic, has been studied for the treatment of mental disorders that require sedative effects, antidepressants, sleep inducers and anxiety reduction. Although more research is needed to fully understand the mechanisms and potential benefits of these compounds, the use of flavonoids for neurological diseases is a promising avenue for future research and development. This review focuses on major flavonoid subclasses and their applications in central nervous system disorders.Keywords: Flavonoidsphytotherapymental disordersherbal medicine Disclosure statementThe authors report there are no competing interests to declare.Additional informationFundingThe author Denise Gonçalves Priolli received funds grant number FAPESP 12/04634-1 associated with work featured in this article.
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