肽YY
白色念珠菌
生物
微生物学
肠内分泌细胞
抗菌肽
共生
肽
分泌物
酵母
分泌蛋白
细胞生物学
粘液
抗菌剂
生物化学
细菌
神经肽
内分泌系统
神经肽Y受体
激素
遗传学
受体
生态学
作者
Joseph F. Pierre,Brian M. Peters,Diana La Torre,Ashley M. Sidebottom,Yun Tao,Xiaorong Zhu,Candace M. Cham,Ling Wang,Amal Kambal,Katharine G. Harris,Julian Furtado Silva,Olga Zaborina,John C. Alverdy,Herbert Herzog,Jessica N. Witchley,Suzanne M. Noble,Vanessa Leone,Eugene B. Chang
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2023-08-03
卷期号:381 (6657): 502-508
被引量:34
标识
DOI:10.1126/science.abq3178
摘要
The mammalian gut secretes a family of multifunctional peptides that affect appetite, intestinal secretions, and motility whereas others regulate the microbiota. We have found that peptide YY (PYY 1-36 ), but not endocrine PYY 3-36 , acts as an antimicrobial peptide (AMP) expressed by gut epithelial paneth cells (PC). PC-PYY is packaged into secretory granules and is secreted into and retained by surface mucus, which optimizes PC-PYY activity. Although PC-PYY shows some antibacterial activity, it displays selective antifungal activity against virulent Candida albicans hyphae—but not the yeast form. PC-PYY is a cationic molecule that interacts with the anionic surfaces of fungal hyphae to cause membrane disruption and transcriptional reprogramming that selects for the yeast phenotype. Hence, PC-PYY is an antifungal AMP that contributes to the maintenance of gut fungal commensalism.
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