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Lymphocyte-to-Monocyte Ratio Is Independently Associated with Progressive Infarction in Patients with Acute Ischemic Stroke

医学 接收机工作特性 改良兰金量表 内科学 曲线下面积 优势比 四分位数 逻辑回归 冲程(发动机) 单变量分析 梗塞 肌酐 心脏病学 多元分析 置信区间 缺血性中风 心肌梗塞 缺血 机械工程 工程类
作者
Xiaocheng Mao,Qiulong Yu,Yunfang Liao,Qin Huang,Si Luo,Shumeng Li,Yuexin Qiu,Yuhang Wu,Jinchong Zhang,Qianxi Chen,Min Zhu,Hui‐Hua Li,Jing Lin,Daojun Hong
出处
期刊:BioMed Research International [Hindawi Limited]
卷期号:2022: 1-9 被引量:8
标识
DOI:10.1155/2022/2290524
摘要

From April 2017 to December 2020, we retrospectively recruited 477 patients with acute ischemic stroke (within 48 hours after onset). Progressive infarction was defined as an increase of ≥1 point in motor power or ≥2 points on the total National Institutes of Health Stroke Scale (NIHSS) within 7 days after admission and extension of the original infarction were further confirmed by diffusion-weighted imaging. Demographic characteristics, clinical information, and neuroimaging characteristics were evaluated after admission. All blood draws and initial imaging were completed within 24 hours of admission.PI occurred in 147 (30.8%) patients. Univariate analysis comparing the two groups revealed that hypertension, initial NIHSS score, discharge NIHSS score, modified Rankin scale score at 90 days, monocyte level, creatinine level, fasting glucose level, LMR, monocyte-to-high-density lipoprotein ratio (MHR), and lesion location were significantly different (P < 0.05). Multivariate logistic regression analysis showed that the odds ratio of PI increased as the quartile of LMR increased, with the lowest quartile as the reference value. Subgroup analyses showed that a high LMR was an independent predictor of PI only in large artery atherosclerosis (LAA) patients. The receiver operating characteristic (ROC) curve was drawn to estimate the predictive value of LMR for PI. For all cases, the area under the curve was 0.583 (95% CI 0.526-0.641), and the best predictive cutoff value was 3.506, with a sensitivity of 53.1% and a specificity of 63.9%. In patients with LAA, the area under the curve was 0.585 (95% CI 0.505-0.665), and the best predictive cutoff value was 3.944, with a sensitivity of 48.7% and a specificity of 72.8%.LMR was an independent predictor for progressive infarction in patients with acute ischemic stroke, especially in LAA cerebral infarction patients.
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