四氯二苯并对二恶英
氧化应激
DNA损伤
DNA
化学
分子生物学
生物化学
生物
毒性
有机化学
作者
Chao Wang,Xiaoxin Liu,Junqiu Zhai,Cuiping Zhong,Hongtao Zeng,Feng Lu,Yunyun Yang,Xinyan Li,Ming Ma,Tiangang Luan,Jiewei Deng
标识
DOI:10.1016/j.jhazmat.2024.134485
摘要
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a highly toxic persistent organic pollutant (POP) that can induce DNA damage within cells. Although oxidative stress is one of the primary mechanisms causing DNA damage, its role in the process of TCDD-induced DNA damage remains unclear. In this study, the TCDD-induced production of reactive oxygen species (ROS) and the occurrence of DNA damage at the AP site were monitored simultaneously. Further investigation revealed that TCDD impaired the activities of superoxide dismutase (SOD) and catalase (CAT), compromising the cellular antioxidant defense system. Consequently, this led to an increase in the production of O
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