作者
Margherita Ambrosini,Benoı̂t Rousseau,Paolo Manca,Oliver Artz,Aurélien Marabelle,Thierry André,G. Maddalena,Giacomo Mazzoli,R. Intini,Romain Cohen,Andrea Cercek,Neil H. Segal,Leonard B. Saltz,Anna M. Varghese,Rona Yaeger,Maliha Nusrat,Zoe Goldberg,Geoffrey Y. Ku,Imane El Dika,Oded Margalit,Albert Grinshpun,Pashtoon Murtaza Kasi,Richard L. Schilsky,Areeb Lutfi,Einat Shacham‐Shmueli,Maaz Khan Afghan,Lena Weiss,C. Benedikt Westphalen,Veronica Conca,Brennan Decker,Giovanni Randon,Elena Élez,Marwan Fakih,Alexa B. Schrock,Chiara Cremolini,Priya Jayachandran,Michael J. Overman,Sara Lonardi,Filippo Pietrantonio
摘要
POLE and POLD1 proofreading deficiency (POLE/D1pd) define a rare subtype of ultramutated metastatic colorectal cancer (mCRC; over 100 mut/Mb). Disease-specific data about the activity and efficacy of immune checkpoint inhibitors (ICIs) in POLE/D1pd mCRC are lacking and it is unknown whether outcomes may be different from mismatch repair-deficient (dMMR)/microsatellite instability-high (MSI-H) mCRCs treated with ICIs.
寻道图强
坚强的广山
海4015
爱静静
带头大哥
柯西
iNk
互助遵法尚德
shinysparrow
Singularity
cannon8
Phosphene
俭朴静竹
pluto
HEIKU
彭于彦祖
合适洋葱
我不爱池鱼
嗯哼
yufanhui
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