An overview on liquisolid technique: its development and applications

With its simplicity and cost-effectiveness, the liquisolid technique offers solutions for numerous formulation problems. Among these are dissolution enhancement and sustaining drug release, and the liquisolid technique dealt with both approaches. This review focuses on the latest advances in the technique. It discusses modified additives for use as carrier materials, which secure the required large surface area for enclosing liquids. The review also covers the modern liquipellet technique derived from the extrusion/palletization technique. Also, the liquiground term is introduced, combining the advantages of co-grinding with the liquisolid concept. Furthermore, several grades of Eudragits, and hydrophilic retarding polymers are mentioned to explain modes of sustaining drug release. This review sums up the liquisolid technique development and its applications recently achieved.What is this review about? This review is about a formulation technique known as ‘liquisolid’. The article discusses the application of this technique in enhancing dissolution of water insoluble drugs and sustaining release of other drugs. It also complies the advances in this technique. How is the review structured? This review gives a highlight on the preparation of liquisolid compacts, the additives used formulation for both enhancing drug dissolution and drug release retardation. The review also includes sections for drug-release enhancement and the advances in this method as liquipellets and liquiground. There is also a section for utilizing this technique to sustain and control drug release. What can we conclude? In its simplicity of formulation, liquisolid techniques fits preparing solid dosage forms for a variety of release patterns.