医学
左乙拉西坦
拉莫三嗪
怀孕
后代
先天性畸形
癫痫
儿科
畸形学
产科
抗癫痫药
胎儿
精神科
遗传学
生物
作者
Rebecca Bromley,Jennifer Weston,Anthony G Marson
出处
期刊:JAMA
[American Medical Association]
日期:2017-11-07
卷期号:318 (17): 1700-1700
被引量:52
标识
DOI:10.1001/jama.2017.14485
摘要
Is maternal use of antiepileptic drugs during pregnancy associated with major congenital malformations in children?Certain antiepileptic drugs were associated with increased rates of congenital malformations (eg, spina bifida, cardiac anomalies). Lamotrigine (2.31% in 4195 pregnancies) and levetiracetam (1.77% in 817 pregnancies) were associated with the lowest risk and valproate was associated with the highest risk (10.93% in 2565 pregnancies) compared with the offspring of women without epilepsy (2.51% in 2154 pregnancies).
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