硝基苯
化学
异氰
钯
叠氮化物
组合化学
催化作用
原子经济
串联
氮原子
偶联反应
光化学
计算化学
有机化学
材料科学
复合材料
群(周期表)
作者
Arshad J. Ansari,Ramdas S. Pathare,Antim K. Maurya,Vijai K. Agnihotri,Shahnawaz Khan,Tapta Kanchan Roy,Devesh M. Sawant,Ram T. Pardasani
标识
DOI:10.1002/adsc.201700928
摘要
Abstract A rapid and elegant tandem azide–isocyanide cross‐coupling/cyclization protocol has been developed based on a nitrene transfer reaction. The palladium‐catalyzed ligand‐free methodology led to the synthesis of three different heterocyclic scaffolds with excellent atom/step/redox economy. Studies based on first‐principles‐based quantum calculations and control experiments unraveled a concerted process of nitrene transfer reaction on isocyanides, ruling out the metallaaziridine intermediate reported earlier. This finding could pave the way for novel applications of nitrene transfer reactions to generate bioactive heterocycles. magnified image
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