已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Immune-Related Adverse Events Associated with Anti-PD-1/PD-L1 Treatment for Malignancies: A Meta-Analysis

医学 阿替唑单抗 无容量 彭布罗利珠单抗 皮疹 内科学 不利影响 胃肠病学 间质性肾炎 肺炎 阿维鲁单抗 肿瘤科 癌症 免疫疗法
作者
Pengfei Wang,Yang Chen,Siying Song,Tingjian Wang,Wenjun Ji,Shouwei Li,Ning Liu,Changxiang Yan
出处
期刊:Frontiers in Pharmacology [Frontiers Media SA]
卷期号:8 被引量:380
标识
DOI:10.3389/fphar.2017.00730
摘要

Background: Treatment of cancers with programmed cell death protein 1 (PD-1) pathway inhibitors can lead to immune-related adverse events (irAEs), which could be serious and even fetal. Therefore, clinicians should be aware of the characteristics of irAEs associated with the use of such drugs. Methods: The MEDLINE, EMBASE, and Cochrane databases were searched to find potential studies using the following strategies: anti-PD-1/PD-L1 treatment; irAEs; and cancer. R© package Meta was used to pool incidence. Results: Forty-six studies representing 12,808 oncologic patients treated with anti-PD-1/PD-L1 agents were included in the meta-analysis. The anti-PD-1/PD-L1 agents included nivolumab, pembrolizumab, atezolizumab, durvalumab, avelumab, and BMS-936559. The tumor types were melanomas, Hodgkin lymphomas, urothelial carcinomas, breast cancers, non-small cell lung cancers, renal cell carcinomas (RCC), colorectal cancers, and others. We described irAEs according to organ systems, namely, the skin (pruritus, rash, maculopapular rash, vitiligo, and dermatitis), endocrine system (hypothyroidism, hyperthyroidism, hypophysitis, thyroiditis, and adrenal insufficiency), digestive system (colitis, diarrhea, pancreatitis, and increased AST/ALT/bilirubin), respiratory system (pneumonitis, lung infiltration, and interstitial lung disease), and urinary system (increased creatinine, nephritis, and renal failure). In patients treated with the PD-1 signaling inhibitors, the overall incidence of irAEs was 26.82% (95% CI, 21.73-32.61; I2, 92.80) in any grade and 6.10% (95% CI, 4.85-7.64; I2, 52.00) in severe grade, respectively. The development of irAEs was unrelated to the dose of anti-PD-1/PD-L1 agents. The incidence of particular irAEs varied when different cancers were treated with different drugs. The incidence of death due to irAEs was around 0.17%. Conclusion: The occurrence of irAEs was organ-specific and related to drug and tumor types.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
我是老大应助tamo采纳,获得10
刚刚
璨澄完成签到 ,获得积分10
3秒前
HB完成签到,获得积分10
5秒前
6秒前
hyf567完成签到,获得积分10
14秒前
tata0215完成签到 ,获得积分10
17秒前
心灵美语兰完成签到 ,获得积分10
17秒前
tamo完成签到,获得积分10
17秒前
汉堡包应助清爽的恋风采纳,获得10
18秒前
18秒前
有川洋一完成签到 ,获得积分10
20秒前
乖巧的菜猪完成签到,获得积分10
21秒前
23秒前
25秒前
坚强豪英完成签到,获得积分10
28秒前
儒雅的傲芙完成签到 ,获得积分10
28秒前
634301059发布了新的文献求助20
30秒前
小蘑菇应助科研通管家采纳,获得10
30秒前
30秒前
30秒前
30秒前
30秒前
30秒前
Orange应助bukeshuo采纳,获得10
31秒前
思源应助乖巧的菜猪采纳,获得10
32秒前
炙热孤容完成签到 ,获得积分10
33秒前
ming发布了新的文献求助10
34秒前
弧光完成签到 ,获得积分10
34秒前
样子完成签到 ,获得积分10
37秒前
38秒前
zhl完成签到,获得积分10
42秒前
43秒前
WerWu完成签到,获得积分10
52秒前
学不完了完成签到 ,获得积分10
53秒前
清爽的恋风完成签到,获得积分10
58秒前
别找了睡觉吧完成签到 ,获得积分10
59秒前
汉堡包应助ming采纳,获得10
59秒前
wujuan完成签到 ,获得积分10
1分钟前
夏天的雪花还能闯天涯吗完成签到,获得积分10
1分钟前
耍酷鼠标完成签到 ,获得积分0
1分钟前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3162246
求助须知:如何正确求助?哪些是违规求助? 2813263
关于积分的说明 7899489
捐赠科研通 2472504
什么是DOI,文献DOI怎么找? 1316446
科研通“疑难数据库(出版商)”最低求助积分说明 631317
版权声明 602142