胰岛素抵抗
内科学
医学
内分泌学
血脂异常
腰围
高脂血症
胰岛素
髓过氧化物酶
体质指数
稳态模型评估
促炎细胞因子
糖尿病
肥胖
炎症
作者
Arturo Carratalá,Sergio Martínez‐Hervás,Enrique Rodríguez–Borja,Eva Benito,José T. Real,Guillermo T. Sáez,Rafael Carmena,Juan F. Ascaso
出处
期刊:Journal of Investigative Medicine
[BMJ]
日期:2018-01-01
卷期号:66 (1): 17-21
被引量:18
标识
DOI:10.1136/jim-2017-000468
摘要
Familial combined hyperlipidemia (FCH) is a primary atherogenic dyslipidemia with insulin resistance and increased cardiovascular risk. Plasminogen activator inhibitor type 1 (PAI-1) and myeloperoxidase (MPO) activity are associated with proinflammatory and atherothrombotic risk. Our aim was to study the role played by PAI-1 and MPO activity in the carotid atherosclerosis prevalence in FCH subjects. 36 FCH unrelated subjects (17 women) were matched by age and body weight with 36 healthy normolipidemic subjects (19 female). Blood lipids, glucose, insulin, insulin resistance (homeostasis model assessment (HOMA)), MPO, and PAI-1 were determined in both groups. Carotid intima media thickness (IMT) was measured by the same investigator by standardized protocol. No differences in age, body mass index (BMI) or waist circumference were observed between the two groups. HOMA and PAI-1 values were higher in the FCH group, reaching statistical significance in those subjects with insulin resistance. In addition, PAI-1 values correlated significantly with metabolic syndrome components and carotid IMT. It is known that the elevated cardiovascular risk that characterizes FCH is frequently associated with insulin resistance. We have detected that two known proinflammatory and proatherothrombotic factors (MPO and PAI-1) are significantly elevated in FCH subjects with insulin resistance. These results could partly explain the high cardiovascular risk present in FCH subjects.
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