热疗
激光器
材料科学
热成像
辐照
热的
温度控制
温度测量
激光功率缩放
微控制器
光电子学
红外线的
光学
电气工程
医学
工程类
机械工程
物理
气象学
核物理学
内科学
量子力学
作者
Shinsuke Nomura,Masashi Arake,Yuji Morimoto,Hironori Tsujimoto,Hiromi Miyazaki,Daizoh Saitoh,Nariyoshi Shinomiya,Kazuo Hase,Junji Yamamoto,Hideki Ueno
摘要
Laser hyperthermia is a powerful therapeutic modality that suppresses the growth of proliferative lesions. In hyperthermia, the optimal temperature range is dependent on the disease; thus, a temperature-driven laser output control system is desirable. Such a laser output control system, integrated with a thermal sensor circuit based on thermography, has been established. In this study, the feasibility of the developed system was examined by irradiating mouse skin. The system is composed of a thermograph, a thermal sensor circuit (PC and microcontroller), and an infrared laser. Based on the maximum temperature in the laser-irradiated area acquired every 100 ms during irradiation, the laser power was controlled such that the maximum temperature was maintained at a preset value. Temperature-controlled laser hyperthermia using the thermal sensor circuit was shown to suppress temperature fluctuations during irradiation (SD ~ 0.14°C) to less than 1/10 of those seen without the thermal sensor circuit (SD ~ 1.6°C). The thermal sensor circuit was able to satisfactorily stabilize the temperature at the preset value. This system can therefore provide noncontact laser hyperthermia with the ability to maintain a constant temperature in the irradiated area.
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