生物正交化学
四嗪
结合
点击化学
化学
抗体-药物偶联物
计算机科学
环辛烯
组合化学
药物输送
跟踪(心理语言学)
生物化学
有机化学
抗体
催化作用
单克隆抗体
语言学
数学分析
免疫学
哲学
医学
数学
作者
Ron M. Versteegen,Raffaella Rossin,Wolter ten Hoeve,Henk M. Janssen,Marc S. Robillard
标识
DOI:10.1002/anie.201305969
摘要
Eliminated without a trace: The fastest click reaction, the highly selective inverse-electron-demand Diels–Alder reaction, has been modified to enable selective bioorthogonal release. Thus, the click reaction of a tetrazine with a drug-bound trans-cyclooctene caused the instantaneous release of the drug and CO2 (see scheme). One possible application is the chemically triggered release, and thereby activation, of a drug from a tumor-bound antibody–drug conjugate. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
科研通智能强力驱动
Strongly Powered by AbleSci AI