鬼臼毒素
细胞毒性
化学
立体化学
细胞毒性T细胞
化学合成
分布(数学)
组合化学
生物化学
体外
数学
数学分析
作者
Marina Gordaliza,Pablo A. García,José M. Miguel del Corral,Arturo San Feliciano,Ma Antonia Gómez-Zurita
出处
期刊:Toxicon
[Elsevier]
日期:2004-09-01
卷期号:44 (4): 441-459
被引量:511
标识
DOI:10.1016/j.toxicon.2004.05.008
摘要
Several podophyllotoxin derivatives modified in the A, B, C, D and E rings were prepared from podophyllotoxin and methyl isoxazopodophyllic acid and evaluated for their cytotoxicity on several neoplastic cell lines. Chemical transformations performed on these compounds have yielded derivatives more potent and more selective that the parent compound. Most of the compounds maintained their cytotoxicity at the μM level. Distribution, biosynthesis, production, biotechnology, applications and synthesis have also been reviewed.
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