聚乙二醇化
乙二醇
药物输送
PLGA公司
内化
PEG比率
纳米颗粒
材料科学
共聚物
毒品携带者
化学
生物物理学
纳米技术
聚乙二醇
生物化学
聚合物
细胞
有机化学
生物
经济
复合材料
财务
作者
Cong‐Fei Xu,Hou-Bing Zhang,Chunyang Sun,Yang Liu,Song Shen,Xianzhu Yang,Yanhua Zhu,Jun Wang
出处
期刊:Biomaterials
[Elsevier]
日期:2016-02-23
卷期号:88: 48-59
被引量:100
标识
DOI:10.1016/j.biomaterials.2016.02.031
摘要
The design of ideal nanoparticle delivery systems should be capable of meeting the requirements of several stages of drug delivery, including prolonged circulation, enhanced accumulation and penetration in the tumor, facilitated cellular internalization and rapid release of the active drug in the tumor cells. However, among the current design strategies, meeting the requirements of one stage often conflicts with the other. Herein, a tumor pH-labile linkage-bridged block copolymer of poly(ethylene glycol) with poly(lacide-co-glycolide) (PEG-Dlinkm-PLGA) was used for siRNA delivery to fulfill all aforementioned requirements of these delivery stages. The obtained siRNA-encapsulating PEG-Dlinkm-PLGA nanoparticle gained efficiently prolonged circulation in the blood and preferential accumulation in tumor sites via the PEGylation. Furthermore, the PEG surface layer was detached in response to the tumor acidic microenvironment to facilitate cellular uptake, and the siRNA was rapidly released within tumor cells due to the hydrophobic PLGA layer. Hence, PEG-Dlinkm-PLGA nanoparticles met the requirements of several stages of drug delivery, and resulted in the enhanced therapeutic effect of the nanoparticular delivery systems.
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