The Physiologic Basis of High-Altitude Diseases

Reviews16 November 2004The Physiologic Basis of High-Altitude DiseasesJohn B. West, MD, PhDJohn B. West, MD, PhDFrom University of California, San Diego, La Jolla, California.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-141-10-200411160-00010 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Clinical PrinciplesThree major high-altitude diseasesAcute mountain sickness (headache, lightheadedness, fatigue, insomnia, anorexia)High-altitude pulmonary edema (dyspnea, reduced exercise tolerance, cough, tachycardia, crepitations)High-altitude cerebral edema (confusion, ataxia, mood changes, coma, papilledema)Other high-altitude conditionsChronic mountain sickness (severe polycythemia, headache, somnolence, fatigue, depression)Subacute mountain sickness (affects infants and adults; right-heart failure with peripheral edema)Retinal hemorrhage (common at extreme altitude but usually causes no visual impairment)Physiologic PrinciplesHypoxia of high altitude impairs physical performance, mental performance, and sleep.In acclimatization, hyperventilation is the most important feature. 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Mountain sickness, retinal haemorrhages, and acclimatisation on Mount Everest in 1975. Br Med J. 1976;2:495-7. [PMID: 953646] CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAuthors: John B. West, MD, PhDAffiliations: From University of California, San Diego, La Jolla, California.Grant Support: By National Institutes of Health grant RO1 HL 60698.Disclosures: None disclosed.Corresponding Author: John B. West, MD, PhD, Department of Medicine, University of California, San Diego, 0623A, 9500 Gilman Drive, La Jolla, CA 92093-0623; e-mail, [email protected]edu. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Physiologic Basis of High-Altitude Diseases Buddha Basnyat The Physiologic Basis of High-Altitude Diseases Anil Pandit The Physiologic Basis of High-Altitude Diseases Matiram Pun The Physiologic Basis of High-Altitude Diseases John B. 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