Wearable glove-embedded sensors for therapeutic drug monitoring in sweat for personalized medicine

可穿戴计算机 微分脉冲伏安法 检出限 分析物 毒品检测 汗水 生物医学工程 材料科学 化学 循环伏安法 计算机科学 电极 色谱法 嵌入式系统 医学 电化学 内科学 物理化学
作者
Paulo A. Raymundo‐Pereira,Nathalia O. Gomes,Sérgio Antônio Spínola Machado,Osvaldo N. Oliveira
出处
期刊:Chemical Engineering Journal [Elsevier]
卷期号:435: 135047-135047 被引量:71
标识
DOI:10.1016/j.cej.2022.135047
摘要

Wearable sensing technology may fulfill the requirements of precision medicine, but the use of on-body devices for rapid, selective screening of therapeutic drugs is relatively new. In this paper, we report on wearable glove-embedded sensors for non-invasive and selective determination of therapeutic drugs and a biomarker in sweat samples. Electrochemical sensing was made with an array of sensors printed on four fingers of a plastic glove. Uric acid was detected using the index finger functionalized with carbon black with a limit of detection of 1.37 × 10–6 mol L–1. Paracetamol and paroxetine were detected using the middle and ring fingers coated with Printex Carbon with limits of detection of 2.47 × 10–7 and 4.93 × 10–7 mol L–1, respectively. Ethinylestradiol (EE2) detection was performed with a pre-treated screen-printed carbon electrode on the little finger with limit of detection of 9.35 × 10–7 mol L–1. The high sensitivity and selectivity achieved with the glove-embedded sensors were possible due to a judicious choice of sensing layers and optimized working conditions for differential pulse voltammetry. Monitoring of the analytes was carried out in sweat samples with suitable recovery between 90 and 110%. The glove-embedded sensors were robust against multiple flexion cycles, stable and reproducible, with no response to interference from other molecules in sweat. They may be extended to detect other targets for on-site analysis, in addition to applications in environmental and water samples.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
搜集达人应助chenxi采纳,获得10
刚刚
1秒前
2秒前
ghy发布了新的文献求助10
2秒前
3秒前
huang发布了新的文献求助10
4秒前
4秒前
monkey发布了新的文献求助10
5秒前
麦益颖完成签到,获得积分10
7秒前
烟花应助听风采纳,获得10
7秒前
hgf发布了新的文献求助10
9秒前
老吴发布了新的文献求助10
9秒前
可爱的函函应助研友_ZGXbo8采纳,获得10
10秒前
酷波er应助水云间采纳,获得10
13秒前
烟花应助曲书文采纳,获得10
15秒前
19秒前
19秒前
英姑应助大气的谷梦采纳,获得10
19秒前
朱江涛完成签到 ,获得积分10
20秒前
郝宝真发布了新的文献求助10
22秒前
XikH完成签到,获得积分20
22秒前
隐形冬亦应助芝士雪豹采纳,获得10
22秒前
23秒前
传奇3应助baobeikk采纳,获得10
24秒前
25秒前
26秒前
eatme发布了新的文献求助10
26秒前
余烬完成签到,获得积分10
27秒前
听风发布了新的文献求助10
30秒前
wsy发布了新的文献求助10
30秒前
研友_ZGXbo8发布了新的文献求助10
31秒前
zha完成签到,获得积分10
31秒前
32秒前
大模型应助耍酷元容采纳,获得10
32秒前
33秒前
韩韩完成签到,获得积分10
33秒前
小二郎应助听风采纳,获得10
34秒前
35秒前
baobeikk发布了新的文献求助10
36秒前
叫我益达完成签到,获得积分10
38秒前
高分求助中
Solution Manual for Strategic Compensation A Human Resource Management Approach 1200
Natural History of Mantodea 螳螂的自然史 1000
Glucuronolactone Market Outlook Report: Industry Size, Competition, Trends and Growth Opportunities by Region, YoY Forecasts from 2024 to 2031 800
A Photographic Guide to Mantis of China 常见螳螂野外识别手册 800
Autoregulatory progressive resistance exercise: linear versus a velocity-based flexible model 500
The analysis and solution of partial differential equations 400
Spatial Political Economy: Uneven Development and the Production of Nature in Chile 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3334409
求助须知:如何正确求助?哪些是违规求助? 2963607
关于积分的说明 8610762
捐赠科研通 2642584
什么是DOI,文献DOI怎么找? 1446799
科研通“疑难数据库(出版商)”最低求助积分说明 670421
邀请新用户注册赠送积分活动 658608