TCRαβ+ CD4−/CD8– “double negative” T cells in health and disease—implications for the kidney

免疫学 发病机制 CD8型 细胞毒性T细胞 T细胞 生物 胃肠道 肾脏疾病 疾病 T细胞受体 医学 免疫系统 病理 内科学 内分泌学 体外 生物化学
作者
Andrea M. Newman-Rivera,Johanna T. Kurzhagen,Hamid Rabb
出处
期刊:Kidney International [Elsevier]
卷期号:102 (1): 25-37 被引量:13
标识
DOI:10.1016/j.kint.2022.02.035
摘要

Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney. Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
gnr2000完成签到,获得积分0
刚刚
1秒前
2秒前
2秒前
卓矢完成签到 ,获得积分10
3秒前
wefor完成签到 ,获得积分10
4秒前
九叶发布了新的文献求助10
5秒前
5秒前
zhangxin完成签到,获得积分10
5秒前
咿呀应助缪甲烷采纳,获得10
5秒前
晟然发布了新的文献求助10
6秒前
6秒前
百甲完成签到,获得积分10
7秒前
7秒前
日安完成签到,获得积分20
8秒前
啧啧zeze发布了新的文献求助10
8秒前
8秒前
wangxiaoqing完成签到,获得积分20
9秒前
晓恬发布了新的文献求助10
9秒前
11秒前
11秒前
woxinyouyou完成签到,获得积分0
11秒前
威武烨磊关注了科研通微信公众号
11秒前
wangxiaoqing发布了新的文献求助10
12秒前
子不语完成签到,获得积分10
13秒前
无聊的爆米花完成签到,获得积分10
14秒前
林楠笙完成签到,获得积分10
16秒前
桐桐应助佳佳采纳,获得10
17秒前
spencer177完成签到,获得积分10
17秒前
日安发布了新的文献求助10
18秒前
CYL07完成签到 ,获得积分10
18秒前
18秒前
Owen应助果实采纳,获得10
18秒前
18秒前
牵墨完成签到,获得积分10
18秒前
田様应助LSY采纳,获得10
19秒前
晟然完成签到,获得积分10
20秒前
AaoTii完成签到,获得积分10
20秒前
周周周周周周完成签到,获得积分10
21秒前
dominate完成签到,获得积分10
21秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3187135
求助须知:如何正确求助?哪些是违规求助? 2837087
关于积分的说明 8013081
捐赠科研通 2499689
什么是DOI,文献DOI怎么找? 1334494
科研通“疑难数据库(出版商)”最低求助积分说明 637194
邀请新用户注册赠送积分活动 605091