TCRαβ+ CD4−/CD8– “double negative” T cells in health and disease—implications for the kidney

免疫学 发病机制 CD8型 细胞毒性T细胞 T细胞 生物 胃肠道 肾脏疾病 疾病 T细胞受体 医学 免疫系统 病理 内科学 内分泌学 体外 生物化学
作者
Andrea M. Newman-Rivera,Johanna T. Kurzhagen,Hamid Rabb
出处
期刊:Kidney International [Elsevier]
卷期号:102 (1): 25-37 被引量:13
标识
DOI:10.1016/j.kint.2022.02.035
摘要

Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney. Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
彩色的德地完成签到,获得积分10
刚刚
行路人完成签到,获得积分10
1秒前
建设完成签到,获得积分10
2秒前
神雕侠完成签到,获得积分10
6秒前
SciGPT应助细心故事采纳,获得10
7秒前
7秒前
Yolo完成签到,获得积分10
9秒前
单薄惜文发布了新的文献求助10
9秒前
10秒前
秃头的彬彬完成签到,获得积分10
11秒前
13秒前
狂野大雄鹰完成签到 ,获得积分10
13秒前
15秒前
甜美的飞丹完成签到,获得积分10
16秒前
blackzabbath发布了新的文献求助10
16秒前
小小王完成签到 ,获得积分10
16秒前
16秒前
DongWei95发布了新的文献求助10
17秒前
烟花应助YXY采纳,获得10
17秒前
17秒前
cheng发布了新的文献求助10
19秒前
Dasha完成签到,获得积分10
19秒前
细心故事完成签到,获得积分10
19秒前
19秒前
蔺烨磊完成签到,获得积分10
19秒前
袁小豪发布了新的文献求助10
20秒前
xlogeman发布了新的文献求助10
21秒前
小王好饿发布了新的文献求助30
21秒前
21秒前
21秒前
Robertchen完成签到,获得积分10
21秒前
WXY发布了新的文献求助10
22秒前
科研通AI2S应助一叶知秋采纳,获得10
25秒前
Ava应助YAE采纳,获得10
25秒前
娃哈哈完成签到,获得积分20
26秒前
大个应助yl采纳,获得10
26秒前
万能图书馆应助小小狗采纳,获得10
28秒前
29秒前
范小小发布了新的文献求助10
30秒前
隐形惋清完成签到,获得积分10
32秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3187888
求助须知:如何正确求助?哪些是违规求助? 2837552
关于积分的说明 8015895
捐赠科研通 2500239
什么是DOI,文献DOI怎么找? 1334820
科研通“疑难数据库(出版商)”最低求助积分说明 637305
邀请新用户注册赠送积分活动 605284