TCRαβ+ CD4−/CD8– “double negative” T cells in health and disease—implications for the kidney

免疫学 发病机制 CD8型 细胞毒性T细胞 T细胞 生物 胃肠道 肾脏疾病 疾病 T细胞受体 医学 免疫系统 病理 内科学 内分泌学 体外 生物化学
作者
Andrea M. Newman-Rivera,Johanna T. Kurzhagen,Hamid Rabb
出处
期刊:Kidney International [Elsevier]
卷期号:102 (1): 25-37 被引量:13
标识
DOI:10.1016/j.kint.2022.02.035
摘要

Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney. Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
欣喜的火龙果完成签到,获得积分10
刚刚
ccm应助完美亦云采纳,获得10
刚刚
宵宵完成签到,获得积分10
1秒前
迈克老狼发布了新的文献求助10
1秒前
YuLu发布了新的文献求助10
1秒前
小兰完成签到,获得积分10
2秒前
3秒前
3秒前
4秒前
Demon724发布了新的文献求助20
4秒前
9秒前
9秒前
罗静完成签到,获得积分10
10秒前
小白完成签到,获得积分10
10秒前
小果冻梨发布了新的文献求助10
11秒前
研友_nv4Bx8完成签到,获得积分10
12秒前
Jasper应助阿明采纳,获得10
14秒前
胖虎完成签到 ,获得积分10
14秒前
领导范儿应助认真的寒香采纳,获得10
18秒前
19秒前
21秒前
hky发布了新的文献求助20
22秒前
dengzzz发布了新的文献求助10
22秒前
22秒前
芋圆不圆完成签到,获得积分10
22秒前
香蕉觅云应助愉快的千亦采纳,获得10
25秒前
坦率的跳跳糖完成签到,获得积分10
25秒前
25秒前
25秒前
26秒前
26秒前
wu完成签到,获得积分20
26秒前
耐万古霉素的建业菌完成签到,获得积分10
28秒前
宇智波白哉完成签到,获得积分10
28秒前
11发布了新的文献求助10
29秒前
29秒前
HappyFlight9898完成签到,获得积分10
31秒前
阿明发布了新的文献求助10
32秒前
33秒前
秋雁风发布了新的文献求助10
35秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
A real-time energy management strategy based on fuzzy control and ECMS for PHEVs 400
Handbook on People's China (1957) 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3189376
求助须知:如何正确求助?哪些是违规求助? 2838682
关于积分的说明 8021170
捐赠科研通 2501595
什么是DOI,文献DOI怎么找? 1335815
科研通“疑难数据库(出版商)”最低求助积分说明 637711
邀请新用户注册赠送积分活动 605784