亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

TCRαβ+ CD4−/CD8– “double negative” T cells in health and disease—implications for the kidney

免疫学 发病机制 CD8型 细胞毒性T细胞 T细胞 生物 胃肠道 肾脏疾病 疾病 T细胞受体 医学 免疫系统 病理 内科学 内分泌学 体外 生物化学
作者
Andrea M. Newman-Rivera,Johanna T. Kurzhagen,Hamid Rabb
出处
期刊:Kidney International [Elsevier]
卷期号:102 (1): 25-37 被引量:13
标识
DOI:10.1016/j.kint.2022.02.035
摘要

Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney. Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
烟花应助hgy采纳,获得10
3秒前
小超哥爱学习完成签到 ,获得积分10
12秒前
1122发布了新的文献求助10
13秒前
17秒前
21秒前
21秒前
CodeCraft应助忐忑的翠彤采纳,获得10
30秒前
设计师做做人完成签到,获得积分10
40秒前
1122完成签到,获得积分20
40秒前
41秒前
害羞龙猫完成签到 ,获得积分10
42秒前
46秒前
Owen应助美好斓采纳,获得10
49秒前
许锦程完成签到,获得积分10
54秒前
口外彭于晏完成签到,获得积分10
56秒前
yang完成签到 ,获得积分10
57秒前
58秒前
美好斓发布了新的文献求助10
1分钟前
siriuslee99完成签到,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
zzh发布了新的文献求助10
1分钟前
hgy发布了新的文献求助10
1分钟前
星孜发布了新的文献求助10
1分钟前
哭泣的丝完成签到 ,获得积分10
1分钟前
张张完成签到 ,获得积分10
1分钟前
古铜完成签到 ,获得积分10
1分钟前
fransiccarey完成签到,获得积分10
1分钟前
嘟嘟嘟完成签到,获得积分10
1分钟前
嘟嘟嘟发布了新的文献求助10
1分钟前
zxt应助彩色德天采纳,获得10
1分钟前
汉堡包应助小齐采纳,获得10
1分钟前
1分钟前
zhenglingying发布了新的文献求助10
1分钟前
三七完成签到,获得积分10
1分钟前
1分钟前
Ade阿德完成签到 ,获得积分10
1分钟前
愤怒的大开完成签到,获得积分10
2分钟前
2分钟前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Mixed-anion Compounds 600
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
Earth System Geophysics 500
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Geochemistry, 2nd Edition 地球化学经典教科书第二版 401
2024 Medicinal Chemistry Reviews 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3200656
求助须知:如何正确求助?哪些是违规求助? 2850433
关于积分的说明 8072042
捐赠科研通 2514175
什么是DOI,文献DOI怎么找? 1346912
科研通“疑难数据库(出版商)”最低求助积分说明 640281
邀请新用户注册赠送积分活动 610407