TCRαβ+ CD4−/CD8– “double negative” T cells in health and disease—implications for the kidney

免疫学 发病机制 CD8型 细胞毒性T细胞 T细胞 生物 胃肠道 肾脏疾病 疾病 T细胞受体 医学 免疫系统 病理 内科学 内分泌学 体外 生物化学
作者
Andrea M. Newman-Rivera,Johanna T. Kurzhagen,Hamid Rabb
出处
期刊:Kidney International [Elsevier]
卷期号:102 (1): 25-37 被引量:13
标识
DOI:10.1016/j.kint.2022.02.035
摘要

Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney. Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
jessie发布了新的文献求助10
刚刚
2秒前
彭于晏应助宣洋采纳,获得10
2秒前
李爱国应助小燚采纳,获得10
2秒前
2秒前
香蕉八宝粥完成签到,获得积分10
3秒前
4秒前
要减肥丸子完成签到,获得积分10
4秒前
4秒前
5秒前
Xiaoyuan完成签到,获得积分10
5秒前
6秒前
6秒前
小蜗牛发布了新的文献求助500
7秒前
8秒前
8秒前
8秒前
岚月发布了新的文献求助10
8秒前
8秒前
Hello应助汎影采纳,获得10
9秒前
石榴完成签到,获得积分10
10秒前
10秒前
10秒前
皮卡啾发布了新的文献求助10
10秒前
11秒前
zrw发布了新的文献求助10
12秒前
12秒前
柠檬酸循环完成签到,获得积分10
12秒前
盈盈关注了科研通微信公众号
12秒前
cgmil完成签到,获得积分10
12秒前
13秒前
w_发布了新的文献求助20
13秒前
13秒前
鲤鱼紫菱发布了新的文献求助10
13秒前
大个应助卡卡采纳,获得10
14秒前
jessie完成签到,获得积分10
14秒前
寒冷靖易完成签到,获得积分10
14秒前
14秒前
小燚发布了新的文献求助10
14秒前
热心太英发布了新的文献求助10
15秒前
高分求助中
Evolution 3rd edition 1500
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
Ribozymes and aptamers in the RNA world, and in synthetic biology 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3181189
求助须知:如何正确求助?哪些是违规求助? 2831405
关于积分的说明 7984596
捐赠科研通 2493399
什么是DOI,文献DOI怎么找? 1330143
科研通“疑难数据库(出版商)”最低求助积分说明 635934
版权声明 602954