TCRαβ+ CD4−/CD8– “double negative” T cells in health and disease—implications for the kidney

免疫学 发病机制 CD8型 细胞毒性T细胞 T细胞 生物 胃肠道 肾脏疾病 疾病 T细胞受体 医学 免疫系统 病理 内科学 内分泌学 体外 生物化学
作者
Andrea M. Newman-Rivera,Johanna T. Kurzhagen,Hamid Rabb
出处
期刊:Kidney International [Elsevier]
卷期号:102 (1): 25-37 被引量:13
标识
DOI:10.1016/j.kint.2022.02.035
摘要

Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney. Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
背后雅绿发布了新的文献求助10
刚刚
听话的蜡烛完成签到,获得积分10
2秒前
CodeCraft应助Pinocchio采纳,获得10
3秒前
谦让文昊完成签到,获得积分10
6秒前
9秒前
15秒前
舒适的晓旋完成签到,获得积分10
18秒前
zong发布了新的文献求助10
19秒前
21秒前
大笨冰完成签到 ,获得积分10
21秒前
大方的雪曼完成签到,获得积分10
23秒前
美满的小蘑菇完成签到 ,获得积分10
24秒前
小音发布了新的文献求助10
26秒前
852应助慧莫如琛采纳,获得10
26秒前
edtaa发布了新的文献求助10
27秒前
28秒前
yhmi0809发布了新的文献求助10
30秒前
weiyi发布了新的文献求助10
31秒前
张伟发布了新的文献求助10
32秒前
共享精神应助shirley要奋斗采纳,获得20
32秒前
希望天下0贩的0应助huihui采纳,获得10
34秒前
36秒前
wing完成签到 ,获得积分10
36秒前
燕燕完成签到 ,获得积分10
37秒前
CC完成签到,获得积分10
38秒前
39秒前
张伟完成签到,获得积分10
39秒前
41秒前
41秒前
姜忆霜完成签到 ,获得积分10
43秒前
liu完成签到,获得积分10
43秒前
jiuyuan135完成签到 ,获得积分10
44秒前
achelc发布了新的文献求助10
44秒前
yhmi0809完成签到,获得积分10
45秒前
辞南发布了新的文献求助10
46秒前
呆呆要努力完成签到 ,获得积分10
50秒前
英姑应助wsqg123采纳,获得10
52秒前
梓泽丘墟完成签到,获得积分10
53秒前
LYegoist完成签到,获得积分10
53秒前
饿哭了塞完成签到 ,获得积分10
56秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Evolution 3rd edition 1500
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3187770
求助须知:如何正确求助?哪些是违规求助? 2837531
关于积分的说明 8015364
捐赠科研通 2500112
什么是DOI,文献DOI怎么找? 1334764
科研通“疑难数据库(出版商)”最低求助积分说明 637295
邀请新用户注册赠送积分活动 605251