TCRαβ+ CD4−/CD8– “double negative” T cells in health and disease—implications for the kidney

免疫学 发病机制 CD8型 细胞毒性T细胞 T细胞 生物 胃肠道 肾脏疾病 疾病 T细胞受体 医学 免疫系统 病理 内科学 内分泌学 体外 生物化学
作者
Andrea M. Newman-Rivera,Johanna T. Kurzhagen,Hamid Rabb
出处
期刊:Kidney International [Elsevier]
卷期号:102 (1): 25-37 被引量:13
标识
DOI:10.1016/j.kint.2022.02.035
摘要

Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney. Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
kento应助树袋熊采纳,获得100
1秒前
晨晨完成签到,获得积分10
2秒前
3秒前
充电宝应助博洋采纳,获得10
4秒前
5秒前
5秒前
lili发布了新的文献求助10
6秒前
keke发布了新的文献求助10
7秒前
张念之发布了新的文献求助10
7秒前
wish完成签到 ,获得积分10
8秒前
老实的逊完成签到,获得积分10
8秒前
8秒前
Apeng完成签到,获得积分10
9秒前
仲半邪发布了新的文献求助10
9秒前
9秒前
星辰大海应助轻松的雨竹采纳,获得10
11秒前
11秒前
aprilvanilla应助轻松的苗条采纳,获得10
12秒前
冰糕发布了新的文献求助20
12秒前
Komorebi完成签到,获得积分10
15秒前
尊敬的毛豆完成签到,获得积分10
15秒前
木木木木完成签到,获得积分10
16秒前
16秒前
科目三应助夏目友人张采纳,获得10
16秒前
仲半邪完成签到,获得积分10
17秒前
Apeng发布了新的文献求助10
18秒前
18秒前
Sherlock发布了新的文献求助10
18秒前
lili完成签到,获得积分10
19秒前
ding应助science采纳,获得10
19秒前
flb完成签到,获得积分10
20秒前
anzi发布了新的文献求助10
20秒前
震动的沉鱼完成签到 ,获得积分10
21秒前
凌忆文完成签到 ,获得积分0
23秒前
6rkuttsmdt完成签到,获得积分10
24秒前
24秒前
奥丁蒂法发布了新的文献求助10
25秒前
Sherlock完成签到,获得积分10
27秒前
28秒前
大模型应助夏目友人张采纳,获得10
30秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
ALA生合成不全マウスでの糖代謝異常の分子機構解析 520
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3193765
求助须知:如何正确求助?哪些是违规求助? 2842801
关于积分的说明 8040948
捐赠科研通 2506913
什么是DOI,文献DOI怎么找? 1339461
科研通“疑难数据库(出版商)”最低求助积分说明 638764
邀请新用户注册赠送积分活动 607589