TCRαβ+ CD4−/CD8– “double negative” T cells in health and disease—implications for the kidney

免疫学 发病机制 CD8型 细胞毒性T细胞 T细胞 生物 胃肠道 肾脏疾病 疾病 T细胞受体 医学 免疫系统 病理 内科学 内分泌学 体外 生物化学
作者
Andrea M. Newman-Rivera,Johanna T. Kurzhagen,Hamid Rabb
出处
期刊:Kidney International [Elsevier]
卷期号:102 (1): 25-37 被引量:13
标识
DOI:10.1016/j.kint.2022.02.035
摘要

Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney. Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
香蕉觅云应助soild采纳,获得10
1秒前
姜姜姜完成签到 ,获得积分10
1秒前
1秒前
1秒前
King丶惠忍完成签到,获得积分10
3秒前
Upupcc关注了科研通微信公众号
4秒前
lin发布了新的文献求助10
4秒前
maibaobao完成签到,获得积分20
5秒前
Cheny发布了新的文献求助10
6秒前
慕青应助魔幻的寒云采纳,获得10
7秒前
9秒前
小二郎应助钱浩采纳,获得10
11秒前
11秒前
12秒前
12秒前
15秒前
SciGPT应助LX采纳,获得10
16秒前
sssss发布了新的文献求助10
16秒前
pysa发布了新的文献求助20
18秒前
18秒前
18秒前
18秒前
欧石楠发布了新的文献求助10
19秒前
眼圆广志完成签到,获得积分10
20秒前
20秒前
20秒前
young发布了新的文献求助10
23秒前
快去吃蛋糕完成签到,获得积分10
23秒前
老北京发布了新的文献求助10
23秒前
23秒前
24秒前
syalonyui完成签到,获得积分10
25秒前
cfpilot完成签到,获得积分10
26秒前
27秒前
JoeC发布了新的文献求助10
27秒前
Finn完成签到,获得积分10
30秒前
31秒前
32秒前
33秒前
young完成签到 ,获得积分10
34秒前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3183276
求助须知:如何正确求助?哪些是违规求助? 2833432
关于积分的说明 7993965
捐赠科研通 2495516
什么是DOI,文献DOI怎么找? 1331557
科研通“疑难数据库(出版商)”最低求助积分说明 636352
邀请新用户注册赠送积分活动 603509