TCRαβ+ CD4−/CD8– “double negative” T cells in health and disease—implications for the kidney

免疫学 发病机制 CD8型 细胞毒性T细胞 T细胞 生物 胃肠道 肾脏疾病 疾病 T细胞受体 医学 免疫系统 病理 内科学 内分泌学 体外 生物化学
作者
Andrea M. Newman-Rivera,Johanna T. Kurzhagen,Hamid Rabb
出处
期刊:Kidney International [Elsevier]
卷期号:102 (1): 25-37 被引量:13
标识
DOI:10.1016/j.kint.2022.02.035
摘要

Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney. Double negative (DN) T cells, one of the least studied T lymphocyte subgroups, express T cell receptor αβ but lack CD4 and CD8 coreceptors. DN T cells are found in multiple organs including kidney, lung, heart, gastrointestinal tract, liver, genital tract, and central nervous system. DN T cells suppress inflammatory responses in different disease models including experimental acute kidney injury, and significant evidence supports an important role in the pathogenesis of systemic lupus erythematosus. However, little is known about these cells in other kidney diseases. Therefore, it is important to better understand different functions of DN T cells and their signaling pathways as promising therapeutic targets, particularly with the increasing application of T cell–directed therapy in humans. In this review, we aim to summarize studies performed on DN T cells in normal and diseased organs in the setting of different disease models with a focus on kidney.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小马快跑完成签到,获得积分10
刚刚
1秒前
1秒前
2秒前
华仔应助称心的问薇采纳,获得10
2秒前
聪明凉面完成签到,获得积分10
2秒前
serendipity发布了新的文献求助10
3秒前
4秒前
con完成签到 ,获得积分10
4秒前
大模型应助huqingtao采纳,获得10
5秒前
5秒前
chenchen完成签到,获得积分10
5秒前
jiujiuhuang完成签到,获得积分10
5秒前
5秒前
Sophia完成签到,获得积分20
6秒前
JINX完成签到,获得积分10
6秒前
zzzzzjzjjjj发布了新的文献求助10
6秒前
SWW发布了新的文献求助10
7秒前
7秒前
Singularity举报21求助涉嫌违规
8秒前
科研通AI2S应助bhfhq采纳,获得30
8秒前
SciGPT应助爱吃洋芋的控工采纳,获得10
9秒前
zjl发布了新的文献求助10
9秒前
10秒前
随便发布了新的文献求助10
11秒前
11秒前
jiose发布了新的文献求助10
12秒前
windsea完成签到,获得积分0
13秒前
橙子发布了新的文献求助10
13秒前
13秒前
onfire完成签到,获得积分10
13秒前
HJZ完成签到,获得积分10
14秒前
15秒前
bhfhq完成签到,获得积分10
16秒前
18秒前
19秒前
慕青应助Astar采纳,获得10
20秒前
20秒前
20秒前
不配.应助科研通管家采纳,获得20
20秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
2024 Medicinal Chemistry Reviews 400
Dictionary of socialism 350
Mixed-anion Compounds 300
Geochemistry, 2nd Edition 地球化学经典教科书第二版 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3195397
求助须知:如何正确求助?哪些是违规求助? 2844229
关于积分的说明 8049314
捐赠科研通 2508912
什么是DOI,文献DOI怎么找? 1341226
科研通“疑难数据库(出版商)”最低求助积分说明 639116
邀请新用户注册赠送积分活动 608214