Undoubtedly, the gut microbiome has emerged as a key influencer of countless human biological processes. Our resident bacteria, viruses, fungi, and archaea colonise virtually all body sites and play pivotal roles in immunity, energy metabolism, and gastrointestinal health. Their influence even extends to the brain, affecting cognitive processes and mental wellbeing. The question is, could we improve brain functioning and behaviour by shifting the landscape of the microbiome?