Research on photocatalysis has boomed in the past two decades as it provides a sustainable solution to degrade organic pollutants. Among the several classes of photocatalyst, metal sulfides have drawn the attention due to its excellent solar spectral response and its notable electrical, optical, mechanical and magnetic properties where MoS2 serves to be a promising one. Various characteristics of MoS2 have rendered it as a preferable photocatalyst as well as a co-catalyst to degrade pharmaceutically active compounds (PhACs). Some of its prominent characteristics include its tunable band gap, enhanced absorption of visible light, layered structure, efficient photon-electron conversion, good photostability, non-toxic nature and quantum confinement effects. PhACs are one of the emerging pollutants of great concern which imparts severe effects on aquatic organisms and human health. This review focuses on the degradation of PhACs by the MoS2 based photocatalysts that has been developed in the recent times. Further, the effect of various parameters that influences the photocatalytic activity of MoS2 towards PhACs has also been discussed.