间充质干细胞
粒体自噬
线粒体
细胞生物学
炎症
生物
化学
自噬
免疫学
细胞凋亡
生物化学
作者
Qiming Zhai,Xin Chen,Dongdong Fei,Xiaoyan Guo,Xiaoning He,Wanmin Zhao,Songtao Shi,J. Justin Gooding,Fang Jin,Yan Jin,Bei Li
标识
DOI:10.1002/advs.202103839
摘要
Mitochondrial dysfunction in tissue-specific mesenchymal stem cells (MSCs) plays a critical role in cell fate and the morbidity of chronic inflammation-associated bone diseases, such as periodontitis and osteoarthritis. However, there is still no effective method to cure chronic inflammation-associated bone diseases by physiologically restoring the function of mitochondria and MSCs. Herein, it is first found that chronic inflammation leads to excess Ca
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